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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Resistance of mice to Leptospira infection and correlation with chemokine response

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Author(s):
Domingos, R. H. [1] ; Pavanel, E. B. [1] ; Nakajima, E. [1] ; Schons-Fonseca, L. [2] ; Da Costa, R. M. A. [3] ; De Franco, M. [4] ; Carvalho, E. [1] ; Ho, P. L. [5] ; Martins, E. A. [1] ; Da Silva, J. B. [1]
Total Authors: 10
Affiliation:
[1] Inst Butantan, Ctr Biotecnol, Av Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil
[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 - USA
[3] GARDP, DNDi, Chemin Louis Dunant 15, CH-1202 Geneva - Switzerland
[4] Inst Butantan, Lab Imunogenet, BR-05503900 Sao Paulo - Brazil
[5] Inst Butantan, Lab Especial Inovacao & Desenvolvimento Ind, BR-05503900 Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Immunobiology; v. 222, n. 11, p. 1004-1013, NOV 2017.
Web of Science Citations: 4
Abstract

Leptospirosis is globally widespread neglected disease, affecting most mammalian species. Clinical signs can be confused with other diseases which make the diagnosis and treatment difficult. Chemokines and cytokines are known for their role in the inflammatory and immune response to infections. The profile determination of chemokines' expressions in the course of infection may elucidate the defense mechanisms of the host and support the search for effective treatment strategies. We investigated the mechanisms of innate immunity through the comparison of chemokines induced during infection with L. interrogans in mice with different levels of susceptibility. We used lung and spleen tissues samples of mice from C3H/HeJ, C3H/HePas and Balb/c, respectively sensitive, intermediate susceptibility and resistant to the pathogen. The inoculation of L. interrogans in C3H/HeJ mice led a comparatively smaller change in chemokines expression in both spleen and lung tissues. In samples from spleens and lungs of C3H/HePas and Balb/c the higher increases occurred on CXCL9, CXCL16, CXCL5, CCL8 and CCL5 in Balb/c. Given the same genetic background, the differences in the responses of C3H/HePas compared to C3H/HeJ mice strongly suggest the role of chemokines for the survival of parental strain. Therefore, the greatest increase in CXC chemokines appears to be efficient to induce migration of cells to the secondary lymphoid organs and affected tissues, which is important to control infection. Overall, CXC chemokines are important for the activation and attraction of T cell and may influence the course and control of the infection in resistant Balb/c mice. (AU)

FAPESP's process: 13/16451-1 - In vitro evaluation of the contribution of CCL2/MCP-1 and the importance of chemokines in the mechanisms of resistance and susceptibility to infection with Leptospira sp.
Grantee:Josefa Bezerra da Silva
Support Opportunities: Regular Research Grants