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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lipidomic alterations of in vitro macrophage infection by L-infantum and L-amazonensis

Full text
Author(s):
Negrao, Fernanda [1, 2] ; Abanades, Daniel R. [2] ; Jaeeger, Caroline F. [1] ; Rocha, Daniele F. O. [1] ; Belaz, Katia R. A. [1] ; Giorgio, Selma [2] ; Eberlin, Marcos N. [1] ; Angolini, Celio F. F. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Lab Leishmaniasis, Dept Anim Biol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MOLECULAR BIOSYSTEMS; v. 13, n. 11, p. 2401-2406, NOV 2017.
Web of Science Citations: 3
Abstract

Particular lipid profiles have been found in two different protozoa of the Leishmania genus. Leishmania infantum, a visceral leishmaniasis causative agent and Leishmania amazonensis, a cutaneous leishmaniasis, reveal distinctive lipid contents of phosphatidylethanolamine and phosphatidylserine plasmalogens, sphingolipids, phosphatidylinositols, phosphatidylcholine, and phosphatidylethanolamine, which have been shown to be related to species, life-cycle of the parasite, and macrophage infection. L. infantum displayed a higher content of phosphatidylethanolamine plasmalogens than L. amazonensis, which may help to differentiate their unique clinical manifestations. Phosphatidylserines plasmalogens are also found to be an important lipid class for the intracellular form of the parasite. Our findings also reveal lipid classes that may be involved in visceralization pathways and parasite differentiation. (AU)

FAPESP's process: 16/11517-2 - Cutaneous leishmaniasis biomarkers candidates search and identification through mass spectrometry
Grantee:Fernanda Negrão Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/23767-0 - Development of biomarkers and Leishmania infantum strains
Grantee:Selma Giorgio
Support Opportunities: Regular Research Grants
FAPESP's process: 12/07206-0 - Search for a Molecular Signature of Receptivity in Cattle by Mass Spectrometry
Grantee:Katia Roberta Anacleto Belaz
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/11100-6 - MALDI-MS proteins and lipids fingerprinting of Fusarium oxysporum f. sp. cubense for intra-species discrimination
Grantee:Daniele Fernanda de Oliveira Rocha
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 10/51677-2 - Development of new mass spectrometry techniques and their general applications in science: chemistry, biochemistry, material sciences, forensics, medicine, food science, pharmaceutical and veterinary medicine
Grantee:Marcos Nogueira Eberlin
Support Opportunities: Research Projects - Thematic Grants