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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of incidence, significance, and prognostic role of circulating tumor microemboli and transforming growth factor-beta receptor I in head and neck cancer

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Fanelli, Marcello Ferretti [1] ; Oliveira, Thiago Bueno [1] ; Braun, Alexcia Camila [2] ; Corassa, Marcelo [2, 1] ; Abdallah, Emne Ali [2] ; Nicolau, Ulisses Ribaldo [1] ; Alves, Vanessa da Silva [2] ; Garcia, Daniel [1] ; Calsavara, Vinicius F. [2] ; Kowalski, Luiz Paulo [3] ; Domingos Chinen, Ludmilla Thome [2]
Total Authors: 11
Affiliation:
[1] AC Camargo Canc Ctr, Dept Med Oncol, Sao Paulo, SP - Brazil
[2] AC Camargo Canc Ctr, Int Res Ctr, Rua Tagua 440, BR-01508010 Sao Paulo, SP - Brazil
[3] AC Camargo Canc Ctr, Dept Otolaryngol Head & Neck Surg, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 39, n. 11, p. 2283-2292, NOV 2017.
Web of Science Citations: 10
Abstract

Background: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-beta (TGF-beta). The purpose of this study was to verify their role in progression-free survival (PFS). Methods: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n553) was analyzed in 2 moments. TGF-beta receptor I (TGFbRI) expression was evaluated by immunocytochemistry. Results: Comparing CTM1 (baseline) with CTM2 (first follow-up), patients with CTM1-positive disease who became CTM2-negative were classified as favorable (PFS 20 months). Patients with unfavorable evolution (CTM1-negative/CTM2-positive), had PFS of 17.5 months. Patients always CTM-negative showed PFS of 22.4 months, those always positive, 4.7 months (P<. 001). The TGF-beta RI expression in the first follow-up correlated with poor PFS (12326 months; P5.007), being an independent prognostic factor (hazard ratio {[}HR] 56.088; P5.033). Conclusion: CTM1/2, TGF-beta RI expression, and unfavorable CTM kinetics may represent poor prognosis in locally advanced HNSCC. (AU)

FAPESP's process: 13/08125-7 - Detection of circulating tumor cells and their correlation with clinical evolution in epidermoid carcinoma of head and neck
Grantee:Ludmilla Thomé Domingos Chinen
Support type: Regular Research Grants