| Full text | |
| Author(s): Show less - |
Fanelli, Marcello Ferretti
[1]
;
Oliveira, Thiago Bueno
[1]
;
Braun, Alexcia Camila
[2]
;
Corassa, Marcelo
[2, 1]
;
Abdallah, Emne Ali
[2]
;
Nicolau, Ulisses Ribaldo
[1]
;
Alves, Vanessa da Silva
[2]
;
Garcia, Daniel
[1]
;
Calsavara, Vinicius F.
[2]
;
Kowalski, Luiz Paulo
[3]
;
Domingos Chinen, Ludmilla Thome
[2]
Total Authors: 11
|
| Affiliation: | [1] AC Camargo Canc Ctr, Dept Med Oncol, Sao Paulo, SP - Brazil
[2] AC Camargo Canc Ctr, Int Res Ctr, Rua Tagua 440, BR-01508010 Sao Paulo, SP - Brazil
[3] AC Camargo Canc Ctr, Dept Otolaryngol Head & Neck Surg, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 39, n. 11, p. 2283-2292, NOV 2017. |
| Web of Science Citations: | 10 |
| Abstract | |
Background: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-beta (TGF-beta). The purpose of this study was to verify their role in progression-free survival (PFS). Methods: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n553) was analyzed in 2 moments. TGF-beta receptor I (TGFbRI) expression was evaluated by immunocytochemistry. Results: Comparing CTM1 (baseline) with CTM2 (first follow-up), patients with CTM1-positive disease who became CTM2-negative were classified as favorable (PFS 20 months). Patients with unfavorable evolution (CTM1-negative/CTM2-positive), had PFS of 17.5 months. Patients always CTM-negative showed PFS of 22.4 months, those always positive, 4.7 months (P<. 001). The TGF-beta RI expression in the first follow-up correlated with poor PFS (12326 months; P5.007), being an independent prognostic factor (hazard ratio {[}HR] 56.088; P5.033). Conclusion: CTM1/2, TGF-beta RI expression, and unfavorable CTM kinetics may represent poor prognosis in locally advanced HNSCC. (AU) | |
| FAPESP's process: | 13/08125-7 - Detection of circulating tumor cells and their correlation with clinical evolution in epidermoid carcinoma of head and neck |
| Grantee: | Ludmilla Thomé Domingos Chinen |
| Support type: | Regular Research Grants |