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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice

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Author(s):
Neto, Aldo Francisco [1] ; Dell'Armelina Rocha, Paulo Ricardo [1] ; Perez, Elizabeth Christina [1] ; Xavier, Jose Guilherme [1] ; Peres, Giovani Bravin [1] ; Spadacci-Morena, Diva Denelle [2] ; Alvares-Saraiva, Anuska Marcelino [1] ; Lallo, Maria Anete [1]
Total Authors: 8
Affiliation:
[1] Univ Paulista UNIP, Programa Patol Ambiental & Expt, Sao Paulo - Brazil
[2] Inst Butantan, Dept Fisiopatol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 12, n. 11 NOV 1 2017.
Web of Science Citations: 3
Abstract

Microsporidiosis are diseases caused by opportunistic intracellular fungi in immunosuppressed individuals, as well as in transplanted patients, the elderly and children, among others. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and decreased T cell response, neutrophil function, humoral immunity failure, increasing the susceptibility to infections. Here, we investigated the susceptibility of streptozotocin (STZ)induced type I diabetic and/or immunosuppressed mice to encephalitozoonosis by Encephalitozoon cuniculi. Microscopically, granulomatous hepatitis, interstitial pneumonia and pielonephritis were observed in all infected groups. STZ treatment induced an immunossupressor effect in the populations of B (B-1 and B2) and CD4(+) T lymphocytes. Moreover, infection decreased CD4(+) and CD8(+) T lymphocytes and macrophages of DM mice. Furthermore, infection induced a significant increase of IL-6 and TNF-alpha cytokine serum levels in DM mice. IFN-y, the most important cytokine for the resolution of encephalitozoonosis, increased only in infected mice. In addition to the decreased immune response, DM mice were more susceptible to encephalitozoonosis, associated with increased fungal burden, and symptoms. Additionally, cyclophosphamide immunosuppression in DM mice further increased the susceptibility to encephalitozoonosis. Thus, microsporidiosis should be considered in the differential diagnosis of comorbidities in diabetics. (AU)

FAPESP's process: 12/51727-5 - The role of B-1 cells in experimental infection with Encephalitozoon cuniculi in mice
Grantee:Maria Anete Lallo
Support Opportunities: Regular Research Grants