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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Personality measures after gamma ventral capsulotomy in intractable OCD

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Author(s):
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Paiva, Raquel R. [1, 2] ; Batistuzzo, Marcelo C. [1] ; McLaughlin, Nicole C. [3] ; Canteras, Miguel M. [4] ; de Mathis, Maria E. [1] ; Requena, Guaraci [1] ; Shavitt, Roseli G. [1] ; Greenberg, Benjamin D. [3, 5] ; Noren, Georg [6] ; Rasmussen, Steven A. [3] ; Tavares, Hermano [1] ; Miguel, Euripedes C. [1] ; Lopes, Antonio C. [1] ; Hoexter, Marcelo Q. [1, 2]
Total Authors: 14
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Dept & Inst Psychiat, Fac Med, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Sao Paulo, SP - Brazil
[3] Brown Univ, Dept Psychiat & Human Behav, Butler Hosp, Warren Alpert Med Sch, Providence, RI 02912 - USA
[4] Hosp Santa Paula, Inst Neurol Radiosurg, Sao Paulo - Brazil
[5] Providence VA Med Ctr, Ctr Neurorestorat & Neurol, Providence, RI - USA
[6] Brown Univ, Dept Neurosurg, Warren Alpert Med Sch, Providence, RI 02912 - USA
Total Affiliations: 6
Document type: Journal article
Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 81, p. 161-168, FEB 2 2018.
Web of Science Citations: 3
Abstract

Background: Neurosurgeries such as gamma ventral capsulotomy (GVC) are an option for otherwise intractable obsessive-compulsive disorder (OCD) patients. In general, clinical and neuropsychological status both improve after GVC. However, its consequences on personality traits are not well-studied. The objective of this study was to investigate personality changes after one year of GVC in intractable OCD patients. Methods: The personality assessment was conducted using the Revised NEO Personality Inventory (NEO PI-R) and Cloninger's Temperament and Character Inventory (TCI) in 14 intractable OCD patients before and one year after GVC. Comparisons of personality features between treatment responders (n = 5) and non-responders (n = 9) were performed. Multiple linear regression was also used for predicting changes in clinical and global functioning variables. Results: Overall, no deleterious effect was found in personality after GVC. Responders had a reduction in neuroticism (p = 0.043) and an increase in extraversion (p = 0.043). No significant changes were observed in nonresponders. Increases in novelty seeking and self-directedness, and decreases in persistence and cooperativiness predicted OCD symptom improvement. Similary, improvement in functioning was also predicted by hgher novelty seeking and self-directedness after GVC, whereas better functioning was also associated with lower reward dependence and cooperativeness after surgery. Conclusions: The pattern of changes in personality traits after GVC was generally towards that observed in nonclinical population, and does not raise safety concerns. (AU)

FAPESP's process: 16/05865-8 - Ventromedial prefrontal cortex metabolite levels in obsessive-compulsive patients: a proton magnetic resonance spectroscopy study
Grantee:Marcelo Camargo Batistuzzo
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/21357-9 - Research on neural circuits and biological markers involved in obsessive-compulsive disorder using behavioral paradigms of fear and anxiety
Grantee:Eurípedes Constantino Miguel Filho
Support Opportunities: Research Projects - Thematic Grants