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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Accuracy of spirometry for detection of asthma: a cross-sectional study

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Author(s):
Cristina Meneghini, Andrea [1, 2] ; Botto Paulino, Ana Carolina [1, 2] ; Pereira, Luciano Penha [1, 3] ; Vianna, Elcio Oliveira [1, 4]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Univ Hosp, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, FMRP, Dept Social Med, Ribeirao Preto, SP - Brazil
[3] Hosp Santa Casa Ribeirao Preto, Serv Pneumol, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, FMRP, Dept Med, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: São Paulo Medical Journal; v. 135, n. 5, p. 428-433, SEP-OCT 2017.
Web of Science Citations: 0
Abstract

ABSTRACT BACKGROUND: Asthma is a chronic inflammatory disease with airway hyperresponsiveness. Spirometry is the most commonly used test among asthmatic patients. Another functional test used for diagnosing asthma is the bronchial challenge test. The aim of this study was to analyze the accuracy of spirometry for detecting asthma in the general population. DESIGN AND SETTING: Cross-sectional study with data analysis to evaluate the accuracy of spirometry through calculating sensitivity, specificity and predictive values and through the kappa agreement test. METHODS: Subjects who constituted a birth cohort were enrolled at the age of 23 to 25 years. Spirometric abnormality was defined as reduced forced expiratory volume in one second, i.e. lower than 80% of the predicted value. Measurement of bronchial responsiveness was performed by means of the bronchial challenge test with methacholine. The gold-standard diagnosis of asthma was defined as the presence of bronchial hyperresponsiveness in association with respiratory symptoms. RESULTS: Asthma was detected in 200 subjects (10.4%) out of the sample of 1922 individuals. Spirometric abnormality was detected in 208 subjects (10.9%) of the sample. The specificity of spirometric abnormality for detecting asthma was 90%, sensitivity was 23%, positive predictive value was 22%, and negative predictive value was 91%. The kappa test revealed weak agreement of 0.13 (95% confidence interval, CI: 0.07-0.19) between spirometry and the diagnosis of asthma. CONCLUSION: Spirometry, as a single test, has limitations for detecting asthma in the general population. (AU)