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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Two-component signal transduction systems in oral bacteria

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Author(s):
Mattos-Graner, Renata O. [1] ; Duncan, Margaret J. [2]
Total Authors: 2
Affiliation:
[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Sao Paulo - Brazil
[2] Forsyth Inst, Dept Oral Med Infect & Immun, Cambridge, MA 02142 - USA
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF ORAL MICROBIOLOGY; v. 9, NOV 27 2017.
Web of Science Citations: 11
Abstract

We present an overview of how members of the oral microbiota respond to their environment by regulating gene expression through two-component signal transduction systems (TCSs) to support conditions compatible with homeostasis in oral biofilms or drive the equilibrium toward dysbiosis in response to environmental changes. Using studies on the sub-gingival Gram-negative anaerobe Porphyromonas gingivalis and Gram-positive streptococci as examples, we focus on the molecular mechanisms involved in activation of TCS and species specificities of TCS regulons. (AU)

FAPESP's process: 15/12940-3 - Identification of surface proteins of Streptococcus mutans involved in evasion of opsonization by the complement system
Grantee:Renata de Oliveira Mattos Graner
Support type: Regular Research Grants
FAPESP's process: 12/50966-6 - Analysis of the roles of the transchptional regulators VicRK and CovR in the susceptibility of Streptococcus mutans and Streptococcus sanguinis to opsonization by the complement system
Grantee:Renata de Oliveira Mattos Graner
Support type: Regular Research Grants