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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A tiered approach to assess effects of diclofenac on the brown mussel Perna perna: A contribution to characterize the hazard

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Fontes, Mayana Karoline [1, 2] ; Gusso-Choueri, Paloma Kachel [2] ; Maranho, Luciane Alves [3, 1] ; de Souza Abessa, Denis Moledo [2] ; Mazur, Wesley Almeida [3, 4] ; de Campos, Bruno Galvao [2] ; Guimaraes, Luciana Lopes [3, 4] ; de Toledo, Marcos Sergio [4] ; Lebre, Daniel [5] ; Marques, Joyce Rodrigues [5] ; Felicio, Andreia Arantes [6] ; Cesar, Augusto [3, 1] ; Almeida, Eduardo Alves [7] ; Seabra Pereira, Camilo Dias [3, 1]
Total Authors: 14
[1] Univ Fed Sao Paulo, Dept Ciencias Mar, Rua Maria Maximo 168, BR-11030100 Santos - Brazil
[2] Univ Estadual Paulista, Inst Biociencias, Campus Litoral Paulista, Infante Dom Henrique S-N, BR-11330900 Sao Vicente - Brazil
[3] Univ Santa Cecilia, Lab Ecotoxicol, Rua Oswaldo Cruz 266, BR-11045907 Santos - Brazil
[4] Univ Fed Sao Paulo, Dept Bioquim, Rua Botucatu 862, BR-04023901 Sao Paulo - Brazil
[5] CIETEC IPEN, CEMSA Ctr Espectrometria Massas Aplicada, Av Prof Lineu Prestes 2242, Salas 112 & 113, BR-05508000 Sao Paulo - Brazil
[6] Univ Estadual Paulista, Campus Sao Jose do Rio Preto, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[7] Fundacao Univ Reg Blumenau, Rua Antonio da Veiga 498, BR-89030103 Itoupava Seca, Blumenau - Brazil
Total Affiliations: 7
Document type: Journal article
Source: WATER RESEARCH; v. 132, p. 361-370, APR 1 2018.
Web of Science Citations: 12

Pharmaceutical discharges into the aquatic ecosystem are of environmental concern and sewage treatment plants (STPs) have been pointed out as the major source of these compounds to coastal zones, where oceanic disposal of sewage occurs through submarine outfalls. Diclofenac (DCF) is one of the most frequently detected pharmaceuticals in water, but little is known about the effects on marine organisms. In this study, we employed a tiered approach involving the determination of environmental concentrations of DCF in marine water and the adverse biological effects for fertilization, embryo-larval development and biomarker responses of the mussel Perna perna. Results indicate that effects in fertilization rate and embryo-larval development were found in the order of mg.L-1. However, low concentrations of DCF (ng.L-1) significantly decreased the lysosomal membrane stability and COX activity, as well as triggered DNA damage, oxidative stress and changes in antioxidant defenses. Our results point to an environmental hazard at coastal ecosystems and suggest the need for improvements in the treatment of domestic wastewater aiming to reduce DCF concentrations, as well as regulation on current environmental legislation and monitoring of aquatic ecosystems. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/11742-0 - Environmental risk assessment of the pharmaceutical diclofenac in marine ambience
Grantee:Mayana Karoline Fontes
Support type: Scholarships in Brazil - Master
FAPESP's process: 06/07005-4 - Membrane microdomains enriched in (glyco) (sphingo) lipds and sterols: organization, function and cell signaling
Grantee:Helio Kiyoshi Takahashi
Support type: Research Projects - Thematic Grants