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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Injectable beta-TCP/MCPM cement associated with mesoporous silica for bone regeneration: characterization and toxicity evaluation

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Author(s):
Mendes, L. S. [1] ; Saska, S. [1] ; Coelho, F. [2] ; de O Capote, T. S. [2] ; Scarel-Caminaga, R. M. [1, 2] ; Marchetto, R. ; Carrodeguas, R. G. [3] ; Gaspar, A. M. M. [2] ; Rodriguez, M. A. [4]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil
[2] Sao Paulo State Univ Unesp, Sch Dent, Araraquara, SP - Brazil
[3] Azurebio SL, Madrid - Spain
[4] CSIC, Inst Ceram & Vidrio, Madrid - Spain
Total Affiliations: 4
Document type: Journal article
Source: Biomedical Materials; v. 13, n. 2 MAR 2018.
Web of Science Citations: 3
Abstract

Calcium phosphate cement has been widely investigated as a bone graft substitute due to its excellent self-setting ability, biocompatibility, osteoconductivity and moldability. In addition, mesoporous materials have been studied as potential materials for application in medical devices due to their large surface area, which is capable of loading numerous biological molecules, besides being bioactive. In this study, bone beta-TCP-MCPM-based injectable cement with mesoporous silica particles was synthesized and characterized in terms of its mechanical properties, microstructure, porosity, injectability, in vitro bioactivity and degradability; together with toxicity effects in CHO-K1 cell culture. The results showed that the beta-TCP-MCPM cement is bioactive after soaking in simulated body fluid solution, and mesoporous silica particles provided better physicochemical properties compared with silica-free cement. Toxicity assays showed low CHO-K1 cell viability after treatment with more concentrated extracts (200 mg ml(-1)). However, this behavior did not compromise the reproductive capacity and did not promote significant DNA damage in those cells. In conclusion, the beta-TCP-MCPM cement associated with mesoporous silica might be considered as a potential bone substitute for the repair and regeneration of bone defects. (AU)

FAPESP's process: 12/21735-6 - Injectable bioactive cements functionalized with osteogenic peptide for bone regeneration
Grantee:Larissa Mendes de Lázari
Support Opportunities: Scholarships in Brazil - Doctorate