| Full text | |
| Author(s): Show less - |
Hibar, D. P.
[1, 2]
;
Westlye, L. T.
[3, 4, 5]
;
Doan, N. T.
[3, 4]
;
Jahanshad, N.
[1]
;
Cheung, J. W.
[1]
;
Ching, C. R. K.
[1, 6]
;
Versace, A.
[7]
;
Bilderbeck, A. C.
[8, 9]
;
Uhlmann, A.
[10, 11]
;
Mwangi, B.
[12]
;
Kraemer, B.
[13]
;
Overs, B.
[14]
;
Hartberg, C. B.
[3]
;
Abe, C.
[15]
;
Dima, D.
[16, 17]
;
Grotegerd, D.
[18]
;
Sprooten, E.
[19]
;
Boen, E.
[20]
;
Jimenez, E.
[21]
;
Howells, F. M.
[10]
;
Delvecchio, G.
[22]
;
Temmingh, H.
[10]
;
Starke, J.
[10]
;
Almeida, J. R. C.
[23]
;
Goikolea, J. M.
[21]
;
Houenou, J.
[24, 25]
;
Beard, L. M.
[26]
;
Rauer, L.
[13]
;
Abramovic, L.
[27]
;
Bonnin, M.
[21]
;
Ponteduro, M. F.
[16]
;
Keil, M.
[28]
;
Rive, M. M.
[29]
;
Yao, N.
[30, 31]
;
Yalin, N.
[32]
;
Najt, P.
[33]
;
Rosa, P. G.
[34, 35]
;
Redlich, R.
[18]
;
Trost, S.
[28]
;
Hagenaars, S.
[36]
;
Fears, S. C.
[37, 38]
;
Alonso-Lana, S.
[39, 40]
;
van Erp, T. G. M.
[41]
;
Nickson, T.
[36]
;
Chaim-Avancini, T. M.
[34, 35]
;
Meier, T. B.
[42, 43]
;
Elvsashagen, T.
[3, 44]
;
Haukvik, U. K.
[3, 45]
;
Lee, W. H.
[19]
;
Schene, A. H.
[46, 47]
;
Lloyd, A. J.
[48]
;
Young, A. H.
[32]
;
Nugent, A.
[49]
;
Dale, A. M.
[50, 51]
;
Pfennig, A.
[52]
;
McIntosh, A. M.
[36]
;
Lafer, B.
[34]
;
Baune, B. T.
[53]
;
Ekman, C. J.
[15]
;
Zarate, C. A.
[49]
;
Bearden, C. E.
[54, 55]
;
Henry, C.
[24, 56]
;
Simhandl, C.
[57]
;
McDonald, C.
[33]
;
Bourne, C.
[8, 9, 58]
;
Stein, D. J.
[10, 11]
;
Wolf, D. H.
[26]
;
Cannon, D. M.
[33]
;
Glahn, D. C.
[30, 31]
;
Veltman, D. J.
[59]
;
Pomarol-Clotet, E.
[39, 40]
;
Vieta, E.
[21]
;
Canales-Rodriguez, E. J.
[39, 40]
;
Nery, F. G.
[60, 34]
;
Duran, F. L. S.
[34, 35]
;
Busatto, G. F.
[34, 35]
;
Roberts, G.
[61, 62]
;
Pearlson, G. D.
[30, 31]
;
Goodwin, G. M.
[8, 9]
;
Kugel, H.
[63]
;
Whalley, H. C.
[36]
;
Ruhe, H. G.
[64, 8, 9, 29]
;
Soares, J. C.
[12]
;
Fullerton, J. M.
[14, 65]
;
Rybakowski, J. K.
[66]
;
Savitz, J.
[43, 67]
;
Chaim, K. T.
[68, 69]
;
Fatjo-Vilas, M.
[39, 40]
;
Soeiro-de-Souza, M. G.
[34]
;
Boks, M. P.
[27]
;
Zanetti, M. V.
[34, 35]
;
Otaduy, M. C. G.
[68, 69]
;
Schaufelberger, M. S.
[34, 35]
;
Alda, M.
[70]
;
Ingvar, M.
[15, 71]
;
Phillips, M. L.
[7]
;
Kempton, M. J.
[16]
;
Bauer, M.
[52]
;
Landen, M.
[15, 72]
;
Lawrence, N. S.
[73]
;
van Haren, N. E. M.
[27]
;
Horn, N. R.
[10]
;
Freimer, N. B.
[74]
;
Gruber, O.
[13]
;
Schofield, P. R.
[14, 65]
;
Mitchell, P. B.
[61, 62]
;
Kahn, R. S.
[27]
;
Lenroot, R.
[14, 61]
;
Machado-Vieira, R.
[75, 34]
;
Ophoff, R. A.
[27, 74]
;
Sarro, S.
[39, 40]
;
Frangou, S.
[19]
;
Satterthwaite, T. D.
[26]
;
Hajek, T.
[70, 76]
;
Dannlowski, U.
[18]
;
Malt, U. F.
[77, 78, 79]
;
Arolt, V.
[18]
;
Gattaz, W. F.
[34]
;
Drevets, W. C.
[80]
;
Caseras, X.
;
Agartz, I.
[3, 20]
;
Thompson, P. M.
[1]
;
Andreassen, O. A.
[3, 4]
;
Working, ENIGMA Bipolar Disorder
Total Authors: 124
|
| Affiliation: Show less - | [1] Univ Southern Calif, Mark & Mary Stevens Inst Neuroimaging & Informat, Imaging Genet Ctr, Marina Del Rey, CA - USA
[2] Janssen Res & Dev, San Diego, CA - USA
[3] Univ Oslo, Inst Clin Med, KG Jebsen Ctr Psychosis Res, NORMENT, Oslo - Norway
[4] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo - Norway
[5] Univ Oslo, Dept Psychol, Oslo - Norway
[6] Univ Calif Los Angeles, Neurosci Interdept Grad Program, Los Angeles, CA - USA
[7] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA - USA
[8] Univ Oxford, Univ Dept Psychiat, Oxford - England
[9] Univ Oxford, Oxford Hlth NHS Fdn Trust, Oxford - England
[10] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town - South Africa
[11] Univ Cape Town, Groote Schuur Hosp J 2, MRC Unit Anxiety & Stress Disorders, Cape Town - South Africa
[12] Univ Texas Hlth Sci Ctr Houston, UT Ctr Excellence Mood Disorders, Dept Psychiat & Behav Sci, Houston, TX 77030 - USA
[13] Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg - Germany
[14] Neurosci Res Australia, Sydney, NSW - Australia
[15] Karolinska Inst, Osher Ctr, Dept Clin Neurosci, Stockholm - Sweden
[16] Kings Coll London, Inst Psychiat Psychol & Neurosci, London - England
[17] City Univ London, Dept Psychol, London - England
[18] Univ Munster, Dept Psychiat, Munster - Germany
[19] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 - USA
[20] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo - Norway
[21] Univ Barcelona, Hosp Clin, IDIBAPS, CIBERSAM, Barcelona - Spain
[22] IRCCS E Medea Sci Inst, San Vito Al Tagliamento - Italy
[23] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, Providence, RI 02912 - USA
[24] Univ Paris East, CHU Mondor, APHP, U955, INSERM, Fdn FondaMental, Team Translat Psychiat 15, Creteil - France
[25] CEA Saclay, Psychiat Team, UNIACT Lab, NeuroSpin, Gif Sur Yvette - France
[26] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 - USA
[27] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht - Netherlands
[28] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen - Germany
[29] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Program Mood Disorders, Amsterdam - Netherlands
[30] Yale Univ, Dept Psychiat, New Haven, CT 06520 - USA
[31] Hartford Hosp, Olin Neuropsychiat Res Ctr, Inst Living, Hartford, CT 06115 - USA
[32] Kings Coll London, Ctr Affect Disorders, London - England
[33] Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom NICOG, Clin Neuroimaging Lab, NCBES Galway Neurosci, Ctr Coll Med Nursing & Hlth, Galway - Ireland
[34] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil
[35] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci, Sao Paulo - Brazil
[36] Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian - Scotland
[37] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA - USA
[38] West Los Angeles Vet Adm, Los Angeles, CA - USA
[39] FIDMAG Germanes Hosp Res Fdn, Barcelona - Spain
[40] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid - Spain
[41] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 - USA
[42] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 - USA
[43] Laureate Inst Brain Res, Tulsa, OK - USA
[44] Oslo Univ Hosp, Dept Neurol, Oslo - Norway
[45] Univ Oslo, Dept Adult Psychiat, Oslo - Norway
[46] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen - Netherlands
[47] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen - Netherlands
[48] Newcastle Univ, Northumberland Tyne & Wear NHS Fdn Trust, Acad Psychiat & Northern Ctr Mood Disorders, Newcastle Upon Tyne, Tyne & Wear - England
[49] NIMH, Expt Therapeut & Pathophysiol Branch, Bethesda, MD 20892 - USA
[50] Univ Calif San Diego, Dept Radiol, MMIL, San Diego, CA 92103 - USA
[51] Univ Calif San Diego, Dept Cognit Sci Neurosci & Psychiat, San Diego, CA 92103 - USA
[52] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Psychiat & Psychotherapy, Dresden - Germany
[53] Univ Adelaide, Dept Psychiat, Adelaide, SA - Australia
[54] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA - USA
[55] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA - USA
[56] Inst Pasteur, Unite Percept & Memoire, Paris - France
[57] Bipolar Ctr Wiener Neustadt, Wiener Neustadt - Austria
[58] Newman Univ, Dept Psychol & Counselling, Birmingham, W Midlands - England
[59] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam - Netherlands
[60] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH - USA
[61] Univ New South Wales, Sch Psychiat, Sydney, NSW - Australia
[62] Univ New South Wales, Black Dog Inst, Sydney, NSW - Australia
[63] Univ Munster, Dept Clin Radiol, Munster - Germany
[64] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen - Netherlands
[65] Univ New South Wales, Sch Med Sci, Sydney, NSW - Australia
[66] Poznan Univ Med Sci, Dept Adult Psychiat, Poznan - Poland
[67] Univ Tulsa, Fac Community Med, Tulsa, OK 74104 - USA
[68] Univ Sao Paulo, Dept Radiol, Sao Paulo - Brazil
[69] Univ Sao Paulo, Lab Magnet Resonance Neuroradiol LIM44, Sao Paulo - Brazil
[70] Dalhousie Univ, Dept Psychiat, Halifax, NS - Canada
[71] Karolinska Univ Hosp, Dept Neuroradiol, Stockholm - Sweden
[72] Gothenburg Univ, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg - Sweden
[73] Univ Exeter, Dept Psychol, Exeter, Devon - England
[74] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA - USA
[75] NIMH, NIH, Bethesda, MD 20892 - USA
[76] Natl Inst Mental Hlth, Klecany - Czech Republic
[77] Oslo Univ Hosp, Dept Res & Educ, Div Clin Neurosci, Oslo - Norway
[78] Univ Oslo, Inst Clin Med, Oslo - Norway
[79] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam - Wales
[80] Janssen Res & Dev, Titusville, NJ - USA
Total Affiliations: 80
|
| Document type: | Journal article |
| Source: | MOLECULAR PSYCHIATRY; v. 23, n. 4, p. 932-942, APR 2018. |
| Web of Science Citations: | 88 |
| Abstract | |
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen's d =-0.293; P = 1.71 x 10(-21)), left fusiform gyrus (d =-0.288; P = 8.25 x 10(-21)) and left rostral middle frontal cortex (d =-0.276; P = 2.99 x 10(-19)). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD. (AU) | |
| FAPESP's process: | 12/23796-2 - "Genetic association study between cognitive performance, polymorphisms of GAD1/Reelin and 3T magnetic ressonance spectroscopy of GABA/glutamate in bipolar I disorder and healthy controls" |
| Grantee: | Márcio Gerhardt Soeiro-de-Souza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 10/18672-7 - SPECGENE: genetic association study between single nucleotide polymorphisms of GAD1 and reelin and magnetic ressonance spectroscopy in bipolar I |
| Grantee: | Ricardo Alberto Moreno |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/03905-4 - NEUROBIOLOGICAL DIFFERENCES BETWEEN TREATMENT-NAIVE PATIENTS WITH BIPOLAR DISORDER SUBTYPES I AND II |
| Grantee: | Marcus Vinicius Zanetti |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 09/14891-9 - Longitudinal study on the neuroprotective and neurotrophic effects of lithium in bipolar disorder: identification of cellular and molecular targets clinically relevant |
| Grantee: | Rodrigo Machado-Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |