| Full text | |
| Author(s): |
Samuel, Renata Oliveira
[1, 2]
;
Gomes-Filho, Joao Eduardo
[1]
;
Azuma, Mariane Maffei
[1, 3]
;
Sumida, Doris Hissako
[4]
;
Penha de Oliveira, Sandra Helena
[4]
;
Chiba, Fernando Yamamoto
[4]
;
Mogami Bomfim, Suely Regina
[5]
;
Ciarlini, Paulo Cesar
[5]
;
Narciso, Luis Gustavo
[5]
;
Angelo Cintra, Luciano Tavares
[1]
Total Authors: 10
|
| Affiliation: | [1] Sao Paulo State Univ Unesp, Sch Dent, Dept Endodont, R Jose Bonifacio 1193, Sao Paulo - Brazil
[2] UNIUBE Univ Uberaba, Sch Dent, Dept Clin Dent, Uberaba, MG - Brazil
[3] UNINGA, Inga Univ Ctr, Dept Endodont, Rod PR 317, 6114 Parque Ind 200, BR-87035510 Maringa, PR - Brazil
[4] Sao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Aracatuba, SP - Brazil
[5] Sao Paulo State Univ Unesp, Sch Vet Med, Dept Vet Clin Lab, Aracatuba, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | CLINICAL ORAL INVESTIGATIONS; v. 22, n. 3, p. 1395-1401, APR 2018. |
| Web of Science Citations: | 6 |
| Abstract | |
The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group. A blood count and cytokine levels were obtained 30 days after infection by collecting blood by cardiac puncture. The maxillae were dissected and stained with hematoxylin and eosin to evaluate the inflammatory infiltrate. The data were tabulated and subjected to statistical analysis (P < 0.05). Histological analysis showed a predominance of mononuclear inflammatory cells. In blood, significant increase of leukocytes, lymphocytes, and tumor necrosis factor alpha (TNF-alpha) in 4AP compared with the control and 1AP groups (P < 0.05) was observed. In addition, significant decrease of interleukin-4 (IL-4) in 1AP and 4AP groups compared with the control was observed (P < 0.05). In the rat model, the presence of multiple AP can affect health by increasing lymphocyte and TNF-alpha levels in the blood. The presence of endodontic infections can interfere with the blood profile, altering systemic health. (AU) | |
| FAPESP's process: | 13/23358-8 - Local and systemic inflammatory profile of rats wistar with multiple endodontics infections |
| Grantee: | Renata Oliveira Samuel |
| Support Opportunities: | Scholarships in Brazil - Doctorate |