The therapeutic strategies against Naegleria fowleri

Author(s)

Bellini, Natalia Karla ^[1] ; Santos, Thomas Michelena ^[1] ; Alves da Silva, Marco Tulio ^[1] ; Thiemann, Otavio Henrique ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Inst Fis Sao Carlos, Caixa Postal 369, BR-13560590 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Genet & Evolucao, Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Experimental Parasitology; v. 187, p. 1-11, APR 2018.
• Web of Science Citations: 4

Abstract

Naegleria fowleri is a pathogenic amoeboflagellate most prominently known for its role as the etiological agent of the Primary Amoebic Meningoencephalitis (PAM), a disease that afflicts the central nervous system and is fatal in more than 95% of the reported cases. Although being fatal and with potential risks for an increase in the occurrence of the pathogen in populated areas, the organism receives little public health attention. A great underestimation in the number of PAM cases reported is assumed, taking into account the difficulty in obtaining an accurate diagnosis. In this review, we summarize different techniques and methods used in the identification of the protozoan in clinical and environmental samples. Since it remains unclear whether the protozoan infection can be successfully treated with the currently available drugs, we proceed to discuss the current PAM therapeutic strategies and its effectiveness. Finally, novel compounds for potential treatments are discussed as well as research on vaccine development against PAM. (C) 2018 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 11/24017-4 - Study of selenium metabolism in primitive eukaryotes
• Grantee: Marco Túlio Alves da Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral