Ivermectin acute administration impaired the spermatogenesis and spermiogenesis of adult rats

Author(s):Show less -

Cordeiro, Flora ^[1] ; Goncalves, Jr., Vagner ^[2] ; Moreira, Natalia ^[2] ; Slobodticov, Joao Iosif ^[1] ; Galvao, Nathalia de Andrade ^[1] ; Spinosa, Helenice de Souza ^[2] ; Bonamin, Leoni Villano ^[1] ; Bondan, Eduardo Fernandes ^[1] ; Pastor Ciscato, Claudia Helena ^[3] ; Barbosa, Claudia Maria ^[3] ; Bernardi, Maria Martha ^[1]

Affiliation

^[1] Univ Paulista, Grad Program Environm & Expt Pathol, Rua Dr Bacelar 1212, BR-04026002 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Grad Program Expt & Comparat Pathol, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil

^[3] Biol Inst, Pesticide Residues Lab, Av Conselheiro Rodrigues Alves 1252, BR-04014002 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Research in Veterinary Science; v. 117, p. 178-186, APR 2018.
• Web of Science Citations: 3

Abstract

Ivermectin (IVM) is an antiparasitic agent widely used in agricultural, domestic animals and in human clinical practice. In the present study, the temporal effects of therapeutic doses of IVM in the morphometric and histological assessment of testis were studied to verify if IVM acute administration impaired the spermatogenesis and spermiogenesis of adult rats, if these effects are reversible. The testosterone levels and the plasmatic IVM levels were assessed. The results show: 1) IVM acute exposure, mainly in the higher dose, reduced the testicular volume, the tubular diameter and the germinal epithelium height; 2) no interferences on Leydig cells frequency; 3) histological studies show that tubular sections containing several histological changes indicative of spermatogenesis interruption, such as disorganization of germinal epithelium, vacuolar degeneration of the germ cells and sloughing of cells into the tubular lumen; 4) no differences in testosterone levels; 5) The IVM plasmatic levels were significantly reduced at 72 h after the 0.2 mg/kg. It was concluded that acute IVM impaired the spermatogenesis and spermiogenesis of rats. Probably these effects were not consequence of IVM at the Leydig cells because no effects were observed at this level. Finally, our results suggest that some testicular effects are reversible and correlated with the plasmatic levels of IVM. (AU)

• FAPESP's process: 15/03131-4 - Effects of exposure to ivermectin in rats: reproductive aspects in male and female
• Grantee: Natalia Moreira
• Support Opportunities: Scholarships in Brazil - Doctorate