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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prostate cancer proteomics: clinically useful protein biomarkers and future perspectives

Full text
Author(s):
Intasqui, Paula [1] ; Bertolla, Ricardo P. [1] ; Sadi, Marcus Vinicius [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Sao Paulo Hosp, Human Reprod Sect, Dept Surg, Div Urol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: EXPERT REVIEW OF PROTEOMICS; v. 15, n. 1, p. 65-79, 2018.
Web of Science Citations: 8
Abstract

Introduction: Although prostate cancer constitutes one of the most important, death-related diseases in the male population, there is still a need for identification of sensitive biomarkers that could precociously detect the disease and differentiate aggressive from indolent cancers, in order to decrease overtreatment. Proteomics research has improved understanding on mechanisms underlying tumorigenesis, cancer cells migration and invasion potential, and castration resistance. This review has focused on proteomic studies of prostate cancer published in the recent years, with a special emphasis on determination of biomarkers for cancer progression and diagnosis. Areas covered: Shotgun and targeted-proteomic studies of prostate cancer in different matrices are reviewed, i.e., prostate tissue, prostate cell lines, blood (serum and plasma), urine, seminal plasma, and exosomes. The most important biomarkers for cancer diagnosis and aggressiveness characterization are highlighted. Expert commentary: In general, results demonstrate alteration in cell cycle control, DNA repair, proteasomal degradation, and metabolic activity. However, these studies suffer from low reproducibility due to heterogeneity of the cancer itself, as well as to techniques utilized for protein identification/quantification. Downstream confirmatory studies in separate cohorts are warranted in order to demonstrate accuracy of these results. (AU)

FAPESP's process: 14/11493-0 - Confirmatory proteomic analysis of a panel of seminal biomarkers of sperm functional abnormalities and semen oxidative stress
Grantee:Paula Intasqui Lopes
Support Opportunities: Scholarships in Brazil - Doctorate