Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?

Author(s)

Faria-Urbina, Mariana ^{[1, 2, 3]} ; Oliveira, Rudolf K. F. ^{[1, 2, 3, 4]} ; Segrera, Sergio A. ^{[1, 2, 3]} ; Lawler, Laurie ^{[1, 2, 3]} ; Waxman, Aaron B. ^{[1, 2, 3]} ; Systrom, David M. ^{[1, 2, 3]}

Affiliation

^[1] Harvard Med Sch, Boston, MA - USA

^[2] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 - USA

^[3] Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 - USA

^[4] Fed Univ Sao Paulo UNIFESP, Dept Med, Div Resp Dis, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: PULMONARY CIRCULATION; v. 8, n. 1 JAN 24 2018.
• Web of Science Citations: 2

Abstract

Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO(2)max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO(2)). We speculate that improved pulmonary hemodynamics at maximum exercise ``unmasked{''} a pre-existing skeletal muscle abnormality. (AU)

• FAPESP's process: 14/12212-5 - Pulmonary hypertension induced by invasive cardiopulmonary exercise testing in patients with fibrotic interstitial lung diseases
• Grantee: Rudolf Krawczenko Feitoza de Oliveira
• Support Opportunities: Scholarships abroad - Research