Iron-Catalyzed Reductive Amination from Levulinic and Formic Acid Aqueous Solutions: An Approach for the Selective Production of Pyrrolidones in Biorefinery Facilities

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Author(s):	Metzker, Gustavo ^[1] ; Dias, Rafael M. P. ^[1] ; Burtoloso, Antonio C. B. ^[1] Total Authors: 3
Affiliation:	^[1] Univ Sao Paulo, Chem Inst Sao Carlos, BR-13560970 Sao Paulo, SP - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	CHEMISTRYSELECT; v. 3, n. 2, p. 368-372, JAN 17 2018.
Web of Science Citations:	8
Abstract
The synthesis of several pyrrolidones (PYR), including a highly complex tetracyclic one (40-91% yields), is described employing an inexpensive iron catalyst and aqueous solutions of biomass-derived levulinic acid (LA) and formic acid (FA). The method is broad since it works with many structurally different amines. Considering that all produced LA from a real biorefinery facility will most probably be further derivatized directly from the hydrolysed biomass in aqueous solutions (without isolation), this method furnishes many advantages when compared to previous ones that employ different solvents or neat LA. (AU)

FAPESP's process:	13/18009-4 - Molecular design, synthesis and trypanocidal activity of cruzain reversible covalent inhibitors
Grantee:	Carlos Alberto Montanari
Support Opportunities:	Research Projects - Thematic Grants


FAPESP's process:	13/17271-7 - The use of new metal Catalysts in Biorefineries: Synthesis of gama-Valerolactones, N-Alkyl-Pyrrolidones and Phenols.
Grantee:	Gustavo Metzker
Support Opportunities:	Scholarships in Brazil - Post-Doctoral