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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human migration and the spread of malaria parasites to the New World

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Author(s):
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Rodrigues, Priscila T. [1] ; Valdivia, Hugo O. [2, 3] ; de Oliveira, Thais C. [1] ; Alves, Joao Marcelo P. [1] ; Duarte, Ana Maria R. C. [4] ; Cerutti-Junior, Crispim [5] ; Buery, Julyana C. [5] ; Brito, Cristiana F. A. [6] ; de Souza, Jr., Julio Cesar [7, 8] ; Hirano, Zelinda M. B. [7, 8] ; Bueno, Marina G. [9] ; Catao-Dias, Jose Luiz [9] ; Malafronte, Rosely S. [10] ; Ladeia-Andrade, Simone [11] ; Mita, Toshihiro [12] ; Santamaria, Ana Maria [13] ; Calzada, Jose E. [13] ; Tantular, Indah S. [14, 15] ; Kawamoto, Fumihiko [16] ; Raijmakers, Leonie R. J. [17] ; Mueller, Ivo [18, 19] ; Pacheco, M. Andreina [20] ; Escalante, Ananias A. [20] ; Felger, Ingrid [21, 22] ; Ferreira, Marcelo U. [1]
Total Authors: 25
Affiliation:
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[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 Sao Paulo - Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Lab Immunol & Parasite Genom, Belo Horizonte, MG - Brazil
[3] US Naval Med Res Unit 6, Bellavista, Callao - Peru
[4] State Secretary Hlth, Superintendency Control Endem SUCEN, Lab Biochem & Mol Biol, Sao Paulo - Brazil
[5] Univ Fed Espirito Santo, Dept Social Med, Vitoria - Brazil
[6] Fundacao Oswaldo Cruz, Rene Rachou Res Ctr, Lab Malaria, Belo Horizonte, MG - Brazil
[7] Univ Reg Blumenau, Blumenau, Blumenau - Brazil
[8] Ctr Biol Res Indaial, Indaial - Brazil
[9] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo - Brazil
[10] Univ Sao Paulo, Inst Trop Med Sao Paulo, Lab Protozool, Sao Paulo - Brazil
[11] Fundacao Oswaldo Cruz, Oswaldo Cruz Inst, Lab Parasit Dis, Rio De Janeiro - Brazil
[12] Juntendo Univ, Sch Med, Dept Trop Med & Parasitol, Tokyo - Japan
[13] Gorgas Mem Inst Hlth, Dept Parasitol, Panama City - Panama
[14] Airlangga Univ, Fac Med, Dept Parasitol, Surabaya - Indonesia
[15] Airlangga Univ, Inst Trop Dis, Surabaya - Indonesia
[16] Oita Univ, Inst Sci Res, Dept Social & Environm Med, Oita - Japan
[17] Univ Oxford, Res Lab Archaeol & Hist Art, Oxford - England
[18] Walter & Eliza Hall Inst Med Res, Div Populat Hlth & Immun, Parkville, Vic - Australia
[19] Inst Pasteur, Dept Parasites & Insect Vectors, Paris - France
[20] Temple Univ, Dept Biol, Inst Genom & Evolutionary Med, Philadelphia, PA 19122 - USA
[21] Swiss Trop & Publ Hlth Inst, Basel - Switzerland
[22] Univ Basel, Basel - Switzerland
Total Affiliations: 22
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JAN 31 2018.
Web of Science Citations: 7
Abstract

We examined the mitogenomes of a large global collection of human malaria parasites to explore how and when Plasmodium falciparum and P. vivax entered the Americas. We found evidence of a significant contribution of African and South Asian lineages to present-day New World malaria parasites with additional P. vivax lineages appearing to originate from Melanesia that were putatively carried by the Australasian peoples who contributed genes to Native Americans. Importantly, mitochondrial lineages of the P. vivax-like species P. simium are shared by platyrrhine monkeys and humans in the Atlantic Forest ecosystem, but not across the Amazon, which most likely resulted from one or a few recent human-to-monkey transfers. While enslaved Africans were likely the main carriers of P. falciparum mitochondrial lineages into the Americas after the conquest, additional parasites carried by Australasian peoples in pre-Columbian times may have contributed to the extensive diversity of extant local populations of P. vivax. (AU)