Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population

Author(s)

Froes Marques Campos, Antonio Hugo Jose ^[1] ; Moreira, Adriana ^[1] ; Ribeiro, Karina Braga ^[2] ; Paes, Roberto Pinto ^[3] ; Zerbini, Maria Claudia ^[4] ; Aldred, Vera ^[3] ; de Souza, Carmino Antonio ^[5] ; Scapulatempo Neto, Cristovam ^{[6, 7]} ; Soares, Fernando Augusto ^{[1, 8, 9]} ; Vassallo, Jose ^{[1, 10]}

Affiliation

^[1] AC Camargo Canc Ctr, Dept Anat Pathol, Sao Paulo - Brazil

^[2] Irmandade Santa Casa Misericordia Sao Paulo, Dept Collect Hlth, Sao Paulo - Brazil

^[3] Irmandade Santa Casa Misericordia Sao Paulo, Dept Anat Pathol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Anat Pathol, Sao Paulo - Brazil

^[5] Univ Estadual Campinas Unicamp, Hematol Clin, Fac Ciencias Med, Campinas, SP - Brazil

^[6] Hosp Canc Barretos, Dept Anat Pathol, Sao Paulo - Brazil

^[7] DASA Diagnost Amer, Barueri, SP - Brazil

^[8] Univ Sao Paulo, Pathol DOr Hosp Network, Sao Paulo - Brazil

^[9] Univ Sao Paulo, Fac Dentristry, Sao Paulo - Brazil

^[10] Univ Estadual Campinas Unicamp, Fac Ciencias Med, Lab Invest Pathol, CIPED, Campinas, SP - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 8, JAN 30 2018.
• Web of Science Citations: 3

Abstract

The epidemiology of classical Hodgkin lymphoma varies significantly in populations with different socioeconomic conditions. Among other changes, improvement in such conditions leads to a reduction in the association with EBV infection and predominance of the nodular sclerosis subtype. This study provides an overview of the epidemiology of 817 cases of classical Hodgkin lymphoma diagnosed in five reference hospitals of the State of Sao Paulo, Brazil, over 54 years (1954-2008). The cases were distributed in 3 periods (1954-1979; 1980-1999; and 2000-2008). EBV-positive cases decreased from 87% to 46%. In children and adolescents (< 15 years) and in young adults (15-45 years), EBV-positive cases decreased respectively from 96% to 64%, and from 85% to 32%. The percentage of male patients declined from 80% to 58%. In older patients (> 45 years), the decrease in EBV infection was not significant. Nodular Sclerosis was the most common subtype in all periods. These results support the hypothesis that, in the Brazilian State of Sao Paulo, classical Hodgkin lymphoma has changed and now shows characteristics consistent with Pattern III observed in populations that experienced a similar socioeconomic transition. (AU)

• FAPESP's process: 09/53389-7 - Detection of oncogenic viruses (EBV, HHV8 e SV40) paraffin embedded tissue of human malignant lymphomas, and correlation with clinicopathological data
• Grantee: José Vassallo
• Support Opportunities: Regular Research Grants