| Full text | |
| Author(s): Show less - |
Dedic, Nina
[1]
;
Kuehne, Claudia
[1]
;
Jakovcevski, Mira
[1]
;
Hartmann, Jakob
[2, 1, 3]
;
Genewsky, Andreas J.
[1]
;
Gomes, Karina S.
[1, 4]
;
Anderzhanova, Elmira
[1]
;
Poehlmann, Max L.
[1]
;
Chang, Simon
[1]
;
Kolarz, Adam
[1]
;
Vogl, Annette M.
[1]
;
Dine, Julien
[1]
;
Metzger, Michael W.
[1]
;
Schmid, Bianca
[1]
;
Almada, Rafael C.
[1]
;
Ressler, Kerry J.
[2, 3]
;
Wotjak, Carsten T.
[1]
;
Grinevich, Valery
[5]
;
Chen, Alon
[1]
;
Schmidt, Mathias V.
[1]
;
Wurst, Wolfgang
[6, 7, 8]
;
Refojo, Damian
[1, 9]
;
Deussing, Jan M.
[1]
Total Authors: 23
|
| Affiliation: | [1] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich - Germany
[2] McLean Hosp, 115 Mill St, Belmont, MA 02178 - USA
[3] Harvard Med Sch, Dept Psychiat, Belmont, MA - USA
[4] Univ Estadual Paulista, Lab Neuropsychopharmacol, Araraquara - Brazil
[5] Heidelberg Univ, Schaller Res Grp Neuropeptides, German Canc Res Ctr, Cent Inst Mental Hlth, Heidelberg - Germany
[6] Helmholtz Zentrum Munchen, Inst Dev Genet, Munich - Germany
[7] Tech Univ Munich, Chair Dev Genet, Munich - Germany
[8] German Ctr Neurodegenerat Dis DZNE, Site Munich, Munich - Germany
[9] Max Planck Gesell, Inst Invest Biomed Buenos Aires IBioBA, CONICET, Partner Inst, Buenos Aires, DF - Argentina
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | NATURE NEUROSCIENCE; v. 21, n. 6, p. 803+, JUN 2018. |
| Web of Science Citations: | 11 |
| Abstract | |
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release. (AU) | |
| FAPESP's process: | 13/03445-3 - Effects of corticotrophin releasing factor (CRF) overexpression and Crf1 and CRF2 receptors knockout within limbic structures on defensive behavior in mice: influence of acute and chronic stress |
| Grantee: | Karina Santos Gomes |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |