Extracellular matrix remodeling and matrix metalloproteinase inhibition in visceral adipoSe during weight cycling in mice

Author(s)

Caria, Cintia Rabelo e Paiva ^[1] ; Ferreira Gotardo, Erica Martins ^[1] ; Santos, Paola Souza ^[1] ; Acedo, Simone Coghetto ^[1] ; de Morais, Thaina Rodrigues ^[1] ; Ribeiro, Marcelo Lima ^[1] ; Gambero, Alessandra ^[1]

Affiliation

^[1] Sao Francisco Univ, Med Sch, Clin Pharmacol & Gastroenterol Unit, BR-12916900 Braganca Paulista, SP - Brazil

• Document type: Journal article
• Source: Experimental Cell Research; v. 359, n. 2, p. 431-440, OCT 15 2017.
• Web of Science Citations: 0

Abstract

Extracellular matrix (ECM) remodeling is necessary for a health adipose tissue (AT) expansion and also has a role during weight loss. We investigate the ECM alteration during weight cycling (WC) in mice and the role of matrix metalloproteinases (MMPs) was assessed using GM6001, an MMP inhibitor, during weight loss (WL). Obesity was induced in mice by a high-fat diet. Obese mice were subject to caloric restriction for WL followed by reintroduction to high-fat diet for weight regain (WR), resulting in a WC protocol. In addition, mice were treated with GM6001 during WL period and the effects were observed after WR. Activity and expression of MMPs was intense during WL. MMP inhibition during WL results in inflammation and collagen content reduction. MMP inhibition during WL period interferes with the period of subsequent expansion of AT resulting in improvements in local inflammation and systemic metabolic alterations induced by obesity. Our results suggest that MMPs inhibition could be an interesting target to improve adipose tissue inflammation during WL and to support weight cyclers. (AU)

• FAPESP's process: 14/10141-3 - Weight cycling: mast cell role, vascular and tissue remodeling and inflammation resolution evaluation
• Grantee: Alessandra Gambero
• Support Opportunities: Regular Research Grants