Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats

Full text
Francescato, Heloisa D. C. [1] ; Almeida, Lucas F. [1] ; Reis, Natany G. [1] ; Faleiros, Camila M. [1] ; Papoti, Marcelo [2] ; Costa, Roberto S. [3] ; Coimbra, Terezila M. [1]
Total Authors: 7
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sports Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Kidney & Blood Pressure Research; v. 43, n. 2, p. 582-593, 2018.
Web of Science Citations: 2

Background/Aims: Physical training has beneficial effects on endothelial function and can influence the regeneration of the endothelial cell. We investigated the effect of physical training on cisplatin (CP)-induced acute kidney injury and assessed the impact of training on endothelial structure and function, and on the inflammatory processes in rats. Methods: We injected male Wistar rats subjected to previous physical training in treadmill running (trained, TR) or not (sedentary, SED) with CP (5 mg/kg) (TR+CP and SED+CP groups, respectively). Five days after the injections, blood and urine samples were collected to evaluate renal function and kidneys were harvested for morphological, immunohistochemical, enzyme-linked immunosorbent assay, and analysis of nitric oxide (NO) levels. Results: Rats treated with CP showed increased levels of plasma creatinine and sodium and potassium fractional excretion. These alterations were associated with increase in tubulointerstitial lesions and macrophage number, reduction of endothelial cells, and increased VEGF, vimentin, and alpha-smooth muscle actin expression in the outer renal medulla in the SED+CP group. We also found increased levels of renal IL-1 beta and increased excretion of monocyte chemoattractant protein-1 and transforming growth factor-beta compared with controls. These changes were milder in trained rats, associated with increased levels of renal tissue NO, and increased expression of p-eNOS and stromal cell-derived factor-1 alpha (a chemokine involved in kidney repair) in the kidneys of CP-injected trained rats. Conclusions: The protective effect of previous training in CP-treated rats was associated with reduced endothelial cell lesions and increased renal production of NO in trained rats. (c) 2018 The Author(s) Published by S. Karger AG, Basel. (AU)

FAPESP's process: 13/23113-5 - Influence of previous physical conditioning on renal tubule cells transdifferentiation from rats with cisplatin-induced renal damage
Grantee:Lucas Chaves
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/50180-2 - Evolution of acute and chronic renal injury in rats submitted to physical preconditioning: involvement of endothelium
Grantee:Heloísa Della Coletta Francescato
Support Opportunities: Research Grants - Young Investigators Grants