Effects of APOE haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in Alzheimer's disease

Author(s)

de Oliveira, Fabricio Ferreira ^[1] ; Pereira, Fernando Vieira ^[1] ; Kamikado Pivi, Glaucia Akiko ^[1] ; Smith, Marilia Cardoso ^[2] ; Ferreira Bertolucci, Paulo Henrique ^[1]

Affiliation

^[1] Fed Univ Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Escola Paulista Med, Sao Paulo - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Escola Paulista Med, Sao Paulo - Brazil

• Document type: Journal article
• Source: International Journal of Neuroscience; v. 128, n. 5, p. 472-476, 2018.
• Web of Science Citations: 6

Abstract

Background: Illiteracy, high cerebrovascular risk and copies of APOE-E4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decline of AD in one year.Methods: Consecutive outpatients with late-onset AD were assessed for gender, schooling, BMI and APOE haplotypes, variations in one year of creatinine clearance and Framingham projections of the 10-year absolute CHD risk, and prospective scores of the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating Sum-of-Boxes (CDR-SOB), the Index of Independence in Activities of Daily Living (ADL) and Lawton's Scale for Instrumental Activities of Daily Living (IADL).Results: For 191 patients, mean age at AD onset was 73.266.4 years-old, earlier for APOE-E4/E4 carriers (p = 0.0039). For women, higher BMI led to improvements in CDR-SOB ( = -0.091; p = 0.037) and MMSE ( = 0.126; p = 0.017) scores, while increased creatinine clearance was associated with improvements in ADL ( = 0.028; p = 0.012) and MMSE ( = 0.043; p = 0.039) scores and higher schooling led to faster worsening of IADL ( = -0.195; p = 0.022) scores. No variables impacted cognitive or functional decline for men, whereas copies of APOE-E4 and the CHD risk had no significant effects whatsoever.Conclusions: Higher BMI and creatinine clearance are protective regarding cognitive and functional decline for women, whereas higher cognitive reserve may lead to faster decline in instrumental functionality. APOE haplotypes affected the age at AD onset, but not cognitive or functional decline. (AU)

• FAPESP's process: 15/10109-5 - Comparative analysis of cerebrospinal fluid and serum markers in dementia with Lewy Bodies and Alzheimer's Disease dementia
• Grantee: Fabricio Ferreira de Oliveira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral