| Full text | |
| Author(s): |
Castanar, Laura
[1]
;
Moutzouri, Pinelopi
[1]
;
Barbosa, Thais M.
[2]
;
Tormena, Claudio F.
[2]
;
Rittner, Roberto
[2]
;
Phillips, Andrew R.
[3]
;
Coombes, Steven R.
[4]
;
Nilsson, Mathias
[1]
;
Morris, Gareth A.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs - England
[2] Univ Estadual Campinas, UNICAMP, Chem Inst, POB 6154, BR-13083970 Campinas, SP - Brazil
[3] AstraZeneca, IMED Biotech Unit, Pharmaceut Sci, Macclesfield SK10 2NA, Cheshire - England
[4] AstraZeneca, Pharmaceut Technol & Dev, Silk Rd Business Pk, Macclesfield SK10 2NA, Cheshire - England
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Analytical Chemistry; v. 90, n. 8, p. 5445-5450, APR 17 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
In complex mixtures, proton nuclear magnetic resonance (NMR) spectra are often very crowded, making spectral analysis complicated or even impossible, particularly when detailed structural information about the mixture components is needed. A new 1D NMR method (fluorine-edited selective TOCSY acquisition, FESTA) is introduced that facilitates the structural analysis of mixtures of species that contain fluorine. It allows simplified H-1 spectra to be obtained that show only those protons that are in a spin system coupled to fluorine of interest. The new method is illustrated by factorizing a complex H-1 spectrum into subspectra for individual spin systems involving different F-19 sites. (AU) | |
| FAPESP's process: | 16/24109-0 - Conformational Analysis of Some Aliphatic Esters Bearing a Nitrogen Atom as a Substituent |
| Grantee: | Roberto Rittner Neto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/12776-6 - Development and application of NMR techniques to analyse complex mixtures |
| Grantee: | Thaís Mendonça Barbosa |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/08541-6 - Nuclear magnetic resonance spectroscopy: beyond molecular structure assignment |
| Grantee: | Claudio Francisco Tormena |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/19229-3 - Multi-way diffusion NMR data analysis applied to chemical reaction monitoring |
| Grantee: | Thaís Mendonça Barbosa |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |