FESTA: An Efficient Nuclear Magnetic Resonance App... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

FESTA: An Efficient Nuclear Magnetic Resonance Approach for the Structural Analysis of Mixtures Containing Fluorinated Species

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Author(s):
Castanar, Laura [1] ; Moutzouri, Pinelopi [1] ; Barbosa, Thais M. [2] ; Tormena, Claudio F. [2] ; Rittner, Roberto [2] ; Phillips, Andrew R. [3] ; Coombes, Steven R. [4] ; Nilsson, Mathias [1] ; Morris, Gareth A. [1]
Total Authors: 9
Affiliation:
[1] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs - England
[2] Univ Estadual Campinas, UNICAMP, Chem Inst, POB 6154, BR-13083970 Campinas, SP - Brazil
[3] AstraZeneca, IMED Biotech Unit, Pharmaceut Sci, Macclesfield SK10 2NA, Cheshire - England
[4] AstraZeneca, Pharmaceut Technol & Dev, Silk Rd Business Pk, Macclesfield SK10 2NA, Cheshire - England
Total Affiliations: 4
Document type: Journal article
Source: Analytical Chemistry; v. 90, n. 8, p. 5445-5450, APR 17 2018.
Web of Science Citations: 2
Abstract

In complex mixtures, proton nuclear magnetic resonance (NMR) spectra are often very crowded, making spectral analysis complicated or even impossible, particularly when detailed structural information about the mixture components is needed. A new 1D NMR method (fluorine-edited selective TOCSY acquisition, FESTA) is introduced that facilitates the structural analysis of mixtures of species that contain fluorine. It allows simplified H-1 spectra to be obtained that show only those protons that are in a spin system coupled to fluorine of interest. The new method is illustrated by factorizing a complex H-1 spectrum into subspectra for individual spin systems involving different F-19 sites. (AU)

FAPESP's process: 16/24109-0 - Conformational Analysis of Some Aliphatic Esters Bearing a Nitrogen Atom as a Substituent
Grantee:Roberto Rittner Neto
Support Opportunities: Regular Research Grants
FAPESP's process: 14/12776-6 - Development and application of NMR techniques to analyse complex mixtures
Grantee:Thaís Mendonça Barbosa
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/08541-6 - Nuclear magnetic resonance spectroscopy: beyond molecular structure assignment
Grantee:Claudio Francisco Tormena
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/19229-3 - Multi-way diffusion NMR data analysis applied to chemical reaction monitoring
Grantee:Thaís Mendonça Barbosa
Support Opportunities: Scholarships abroad - Research Internship - Doctorate