| Full text | |
| Author(s): |
Sonada, Rafael Bazaglia
[1]
;
de Azevedo, Sergio Santos
[2]
;
Martins Soto, Francisco Rafael
[3]
;
da Costa, Diego Figueiredo
[2]
;
de Morais, Zenaide Maria
[1]
;
de Souza, Gisele Oliveira
[1]
;
Goncales, Amane Paldes
[4]
;
Miraglia, Fabiana
[1]
;
Vasconcellos, Silvio Arruda
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, FMVZ, Sao Paulo, SP - Brazil
[2] UFCG, CSTR, Patos de Minas, PB - Brazil
[3] Inst Fed Educ Ciencia & Tecnol Sao Paulo IFSP, Rao Roque, SP - Brazil
[4] Univ Santo Amaro UNISA, Sao Paulo, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Microbiology; v. 49, n. 2, p. 347-350, APR-JUN 2018. |
| Web of Science Citations: | 4 |
| Abstract | |
Abstract In swine and bovines, leptospirosis prevention and control is carried out via vaccination of susceptible animals using bacterins. However, the efficiency of leptospirosis vaccines has been questioned. This work aimed to investigate the potency of five leptospirosis vaccines sold commercially in Brazil, challenging the animals with one autochthonous strain of Leptospira, Canicola serovar, denoted LO4, isolated from swine. The standard protocol was followed, and renal carriers of Leptospira were identified among the surviving animals by culture and PCR. Of the five vaccines tested, only two proved effective. None of the surviving animals was positive by culture; however, one animal was positive by PCR. Three of the five vaccines sold commercially in Brazil for the immunization of swine or bovines failed the test of the efficacy to protect the vaccinated animals following challenge with an autochthonous Leptospira strain, Canicola serovar. The two vaccines provided protection against the renal carrier state in the surviving animals. The criteria used to produce leptospirosis bacterins sold commercially in Brazil must be reviewed. The industry should support researches on leptospiral vaccinology to improve the quality of the present vaccines and discover new immunogenic strains, because it is known that vaccination is one of the most important tools to increase the reproduction rates in livestock. (AU) | |
| FAPESP's process: | 10/17001-1 - Potency test in hasmters of antileptospirosis vaccines produced for the immunization of cattle and swine in Brazil: Challenge with a strain of Pomona serovar isolated from swine in Brazil. |
| Grantee: | Rafael Bazaglia Sonada |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |