Association between Dietary Intake and Coronary Artery Calcification in Non-Dialysis Chronic Kidney Disease: The PROGREDIR Study

Author(s)

Machado, Alisson Diego ^[1] ; Gomez, Luz Marina ^[2] ; Lobo Marchioni, Dirce Maria ^[3] ; Nogueira dos Anjos, Fernanda Silva ^[1] ; Bisi Molina, Maria del Carmen ^[4] ; Lotufo, Paulo Andrade ^{[5, 6]} ; Martins Bensenor, Isabela Judith ^{[5, 6]} ; de Oliveira Titan, Silvia Maria ^[1]

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Dept Nephrol, Fac Med, BR-05403000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Heart Inst, Hosp Clin, Fac Med, BR-05403900 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-03178200 Sao Paulo, SP - Brazil

^[4] Univ Fed Espirito Santo, Hlth Sci Ctr, BR-29043900 Vitoria, ES - Brazil

^[5] Univ Sao Paulo, Fac Med, Gen Med Unit, BR-05508000 Sao Paulo, SP - Brazil

^[6] Univ Sao Paulo, Hosp Univ, BR-05508000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: NUTRIENTS; v. 10, n. 3 MAR 2018.
• Web of Science Citations: 4

Abstract

Coronary artery calcification (CAC) is a widespread condition in chronic kidney disease (CKD). Diet may play an important role in CAC, but this role is not clear. This study evaluated the association between macro-and micronutrient intakes and CAC in non-dialysis CKD patients. We analyzed the baseline data from 454 participants of the PROGREDIR study. Dietary intake was evaluated by a food frequency questionnaire. CAC was measured by computed tomography. After exclusion of participants with a coronary stent, 373 people remained for the analyses. The highest tertile of CAC was directly associated with the intake of phosphorus, calcium and magnesium. There was a higher intake of pantothenic acid and potassium in the second tertile. After adjustments for confounding variables, the intake of pantothenic acid, phosphorus, calcium and potassium remained associated with CAC in the generalized linear mixed models. In order to handle the collinearity between these nutrients, we used the LASSO (least absolute shrinkage and selection operator) regression to evaluate the nutrients associated with CAC variability. In this approach, the nutrients that most explained the variance of CAC were phosphorus, calcium and potassium. Prospective studies are needed to confirmthese findings and assess the role of interventions regarding these micronutrients on CAC prevention and progression. (AU)

• FAPESP's process: 11/17341-0 - Chronic kidney disease: determinants of progression and cardiovascular risk: a cohort study in a brazilian population
• Grantee: Silvia Maria de Oliveira Titan
• Support Opportunities: Regular Research Grants