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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Morphological and Functional inner and Outer retinal layer abnormalities in eyes with Permanent Temporal hemianopia from chiasmal compression

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Author(s):
de Araujo, Rafael B. [1] ; Oyamada, Maria K. [1] ; Zacharias, Leandro C. [1] ; Cunha, Leonardo P. [2] ; Preti, Rony C. [1] ; Monteiro, Mario L. R. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Div Ophthalmol, Lab Invest Ophthalmol LIM 33, Med Sch, Sao Paulo - Brazil
[2] Univ Fed Juiz de Fora, Sch Med, Dept Ophtalmol, Juiz De Fora - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FRONTIERS IN NEUROLOGY; v. 8, DEC 4 2017.
Web of Science Citations: 2
Abstract

Purpose: The aims of this study are to compare optical coherence tomography (OCT)measured macular retinal layers in eyes with permanent temporal hemianopia from chiasmal compression and control eyes; to compare regular and slow-flash multifocal electroretinography (mfERG) in patients and controls; and to assess the correlation between OCT, mfERG, and central visual field (SAP) data. Methods: Forty-three eyes of 30 patients with permanent temporal hemianopia due to pituitary tumors who were previously submitted to chiasm decompression and 37 healthy eyes of 19 controls were submitted to macular spectral domain OCT, mfERG, and 10-2 SAP testing. After segmentation, the thickness of the macular retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer, and photoreceptor layer (PRL) was measured. Amplitudes and oscillatory potentials (OPs) were measured on regular and slow-flash mfERG, respectively, and expressed as the mean values per quadrant and hemifield. Results: RNFL, GCL, and IPL thickness measurements were significantly reduced in all quadrants, whereas INL, OPL, and PRL thicknesses were significantly increased in the nasal quadrants in patients compared to those in controls. Significant correlations between OCT and 10-2 SAP measurements were positive for the RNFL, GCL, and IPL and negative for the INL, OPL, and PRL. OPs and mfERG N1 amplitudes were significantly reduced in the nasal hemiretina of patients. Significant correlations were found between OP and mfERG amplitudes for inner and outer nasal hemiretina OCT measurements, respectively. Conclusion: Patients with permanent temporal hemianopia from previously treated chiasmal compression demonstrated significant thinning of the RNFL, GCL, IPL, and thickening of the INL, OPL, and PRL associated with reduced OP and mfERG N1 amplitudes, suggesting that axonal injury to the inner retina leads to secondary damage to the outer retina in this condition. (AU)

FAPESP's process: 13/26585-5 - Relationship between Spectralis optical coherence tomography with Nsite axonal analytics system, automated perimetry and pattern-reversal or multifocal visual evoked potential in compressive and inflammatory diseases of the anterior visual pathway
Grantee:Mário Luiz Ribeiro Monteiro
Support Opportunities: Regular Research Grants