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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanoecotoxicity assessment of graphene oxide and its relationship with humic acid

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Author(s):
Castro, Vera L. [1, 2] ; Clemente, Zaira [3, 2] ; Jonsson, Claudio [2] ; Silva, Mariana [4] ; Vallim, Jose Henrique [2] ; Zigiotto de Medeiros, Aline Maria [1, 3] ; Martinez, Diego Stefani T. [1, 3]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Ctr Nucl Energy Agr CENA, Sao Paulo - Brazil
[2] Embrapa Environm, Lab Ecotoxicol & Biosafety, Sao Paulo - Brazil
[3] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Natl Nanotechnol Lab LNNano, Sao Paulo - Brazil
[4] Embrapa Environm, Lab Aquat Ecosyst, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Environmental Toxicology and Chemistry; v. 37, n. 7, p. 1998-2012, JUL 2018.
Web of Science Citations: 13
Abstract

The risk assessment of nanomaterials is essential for regulatory purposes and for sustainable nanotechnological development. Although the application of graphene oxide has been widely exploited, its environmental risk is not well understood because several environmental conditions can affect its behavior and toxicity. In the present study, the graphene oxide effect from aquatic ecosystems was assessed considering the interaction with humic acid on 9 organisms: Raphidocelis subcapitata (green algae), Lemna minor (aquatic plant), Lactuca sativa (lettuce), Daphnia magna (planktonic microcrustacean), Artemia salina (brine shrimp), Chironomus sancticaroli (Chironomidae), Hydra attenuata (freshwater polyp), and Caenorhabditis elegans and Panagrolaimus sp. (nematodes). The no-observed-effect concentration (NOEC) was calculated for each organism. The different criteria used to calculate NOEC values were transformed and plotted as a log-logistic function. The hypothetical 5 to 50% hazardous concentration values were, respectively, 0.023 (0.005-0.056) and 0.10 (0.031-0.31) mg L-1 for graphene oxide with and without humic acid, respectively. The safest scenario associated with the predicted no-effect concentration values for graphene oxide in the aquatic compartment were estimated as 20 to 100gL(-1) (in the absence of humic acid) and 5 to 23gL(-1) (in the presence of humic acid). Finally, the present approach contributed to the risk assessment of graphene oxide-based nanomaterials and the establishment of nano-regulations. Environ Toxicol Chem 2018;37:1998-2012. (c) 2018 SETAC (AU)

FAPESP's process: 14/01995-9 - Nanoecotoxicologial evaluation of graphene oxide in Danio rerio (zebrafish): influence of interaction with humic substances
Grantee:Zaira Clemente
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/12891-0 - Nanoecotoxicological evaluation graphene oxide
Grantee:Vera Lucia Scherholz Salgado de Castro
Support type: Regular Research Grants