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Nanoecotoxicologial evaluation of graphene oxide in Danio rerio (zebrafish): influence of interaction with humic substances

Grant number: 14/01995-9
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2017
Field of knowledge:Biological Sciences - Pharmacology - Toxicology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Vera Lucia Scherholz Salgado de Castro
Grantee:Zaira Clemente
Host Institution: Embrapa Meio-Ambiente. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). Jaguariúna , SP, Brazil


Nanostructured graphene oxide has applications in areas such as electronics, pharmaceutical and environmental. Their diverse and promising uses raise concerns about the consequences to human and environmental health of the inappropriate disposal of waste materials and/or products. Despite nanotoxicological studies have been intensified in recent years, gaps still remain in the methods used to assess the nanotechnology risks. It is due to the complex nanomaterials behavior in the environment, especially in the presence of organic matter and depending on the nanomaterial characteristics. The objective of this study is to evaluate the toxicological effects of graphene oxide (GO) by in vivo and in vitro tests with Danio rerio (zebrafish) embryos, considering the influence of the presence of oxidative debris and its interaction with humic substances. For this, it will be evaluated lethal and sublethal parameters, as larvae total length and biochemical biomarkers of metabolism (activity of glutathione S-transferase and acid phosphatase), oxidative stress (activity of catalase) and neurotoxicity (acetylcholinesterase activity). It is expected to contribute to the establishment of analytical protocols and participate in the consolidation of nanoecotoxicology in Brazil, providing information to complement the knowledge about nanotechnology to the living organisms and ecosystems. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTRO, VERA L.; CLEMENTE, ZAIRA; JONSSON, CLAUDIO; SILVA, MARIANA; VALLIM, JOSE HENRIQUE; ZIGIOTTO DE MEDEIROS, ALINE MARIA; MARTINEZ, DIEGO STEFANI T.. Nanoecotoxicity assessment of graphene oxide and its relationship with humic acid. Environmental Toxicology and Chemistry, v. 37, n. 7, p. 1998-2012, . (14/12891-0, 14/01995-9)
CLEMENTE, ZAIRA; SILVA, GABRIELA HELENA; DE SOUZA NUNES, MIRIAM CELI; TEODORO MARTINEZ, DIEGO STEFANI; MAURER-MORELLI, CLAUDIA VIANNA; THOMAZ, ANDRE ALEXANDRE; SCHERHOLZ SALGADO CASTRO, VERA LUCIA. Exploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish. Environmental Science and Pollution Research, v. 26, n. 29, p. 30508-30523, . (14/15640-8, 14/01995-9, 14/12891-0)
CLEMENTE, ZAIRA; CASTRO, VERA LUCIA S. S.; FRANQUI, LIDIANE S.; SILVA, CRISTIANE A.; MARTINEZ, DIEGO STEFANI T.. Nanotoxicity of graphene oxide: Assessing the influence of oxidation debris in the presence of humic acid. Environmental Pollution, v. 225, p. 118-128, . (14/12891-0, 14/01995-9)
COA, FRANCINE; STRAUSS, MATHIAS; CLEMENTE, ZAIRA; RODRIGUES NETO, LAIA L.; LOPES, JOSIAS R.; ALENCAR, RAFAEL S.; SOUZA FILHO, ANTONIO G.; ALVES, OSWALDO L.; CASTRO, VERA LUCIA S. S.; BARBIERI, EDISON; et al. Coating carbon nanotubes with humic acid using an eco-friendly mechanochemical method: Application for Cu(II) ions removal from water and aquatic ecotoxicity. Science of The Total Environment, v. 607, p. 1479-1486, . (14/01995-9)

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