| Full text | |
| Author(s): |
da Silva, Roberta Fernanda
[1]
;
Lacchini, Riccardo
[2]
;
Pinheiro, Lucas Cezar
[3]
;
Dionisio, Thiago Jose
[4]
;
Jacomini, Andre Mourao
[1]
;
Tanus-Santos, Jose Eduardo
[3]
;
Amaral, Sandra Lia
[1]
;
Santos, Carlos Ferreira
[4]
;
Zago, Anderson Saranz
[1]
Total Authors: 9
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Sch Sci, Dept Phys Educ, Ave Engn Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP - Brazil
[2] Univ Sao Paulo, Sch Nursing Ribeirao Preto, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Bauru Sch Dent, Bauru - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM; v. 19, n. 2 JUN 20 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Objective: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. Methods: A total of 155 elderly participants performed the following assessments: general functional fitness index (GFFI), systolic BP (SBP) and diastolic BP (DBP), blood collection for ACE activity and analyses of the RAS polymorphisms. Results: Uncontrolled hypertensive (UHT) participants presented higher values of SBP and DBP compared with normotensive (NT) and controlled hypertensive (CHT) participants. No differences were found in ACE activity and GFFI between groups. In the high risk group, UHT presented higher values of SBP and DBP compared with other groups. CHT presented higher values of SBP compared with NT. Furthermore, UHT presented higher values of ACE activity compared with CHT and lower values of GFFI compared with NT. Conclusion: MDA, TIA and TIC genetic combinations were associated with high risk of developing hypertension while the maintenance of good levels of TS was associated with lower BP values and ACE activity. (AU) | |
| FAPESP's process: | 15/24847-8 - Comparative analysis of the mechanisms involved in the regulation of blood pressure during acute physical exercise in adults and elderly, hypertensive and normotensive and individuals with different level of training status |
| Grantee: | Anderson Saranz Zago |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach |
| Grantee: | Carlos Ferreira dos Santos |
| Support Opportunities: | Research Projects - Thematic Grants |