Insights into Anti-Trypanasornal Agents Based on Synthetic Glycoconjugates

Author(s)

Campo, Vanessa Leiria ^[1] ; Marchiori, Marcelo Fiori ^[1] ; Carvalho, Ivone ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: CURRENT TOPICS IN MEDICINAL CHEMISTRY; v. 18, n. 5, p. 382-396, 2018.
• Web of Science Citations: 3

Abstract

Chagas disease is still a worldwide threat, with estimated 6 to 7 million infected people, mainly in Latin America. Current treatments still rely only on benznidazol and nifurtimox, drugs with poor efficacy in chronic infection phase and recognized toxicity. Thus, there is an urgent need for new therapeutic agents against this disease. In this review we present an updated selection over the last decade of synthetic glycoconjugates as anti-trypanosomal agents, properly addressed as monosaccharide-and disaccharide-based agents, and multivalent-based derivatives, disclosing relevant methods for their synthesis, along with their activities on T. cruzi and its trans-sialidase (TcTS). In addition, synthetic glycoconjugates as potential vaccines and diagnostic antigens against T. cruzi are also reported. (AU)

• FAPESP's process: 12/19390-0 - Development of mucin glycoconjugates with diagnostic and therapeutic applications in muscular dystrophies and cancer
• Grantee: Vanessa Leiria Campo
• Support Opportunities: Research Grants - Young Investigators Grants