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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Social context influences the expression of DNA methyltransferase genes in the honeybee

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Author(s):
Mendes Cardoso-Junior, Carlos Antonio [1] ; Eyer, Michael [2] ; Dainat, Benjamin [2] ; Hartfelder, Klaus [1] ; Dietemann, Vincent [2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Biol Celular Mol & Bioagentes Patogen, Fac Med Ribeirao Preto, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Swiss Bee Res Ctr, Agroscope, Schwarzenburgstr 161, CH-3003 Bern - Switzerland
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JUL 23 2018.
Web of Science Citations: 5
Abstract

DNA methylation is a reversible epigenetic modification that alters gene expression without altering the nucleotide sequence. Epigenetic modifications have been suggested as crucial mediators between social interactions and gene expression in mammals. However, little is known about the role of DNA methylation in the life cycle of social invertebrates. Recently, honeybees have become an attractive model to study epigenetic processes in social contexts. Although DNA methyltransferase (DNMT) enzymes responsible for DNA methylation are known in this model system, the influence of social stimuli on this process remains largely unexplored. By quantifying the expression of DNMT genes (dnmt1a, dnmt2 and dnmt3) under different demographical conditions characterized by the absence or presence of immatures and young adults, we tested whether the social context affected the expression of DNMT genes. The three DNMT genes had their expression altered, indicating that distinct molecular processes were affected by social interactions. These results open avenues for future investigations into regulatory epigenetic mechanisms underlying complex traits in social invertebrates. (AU)

FAPESP's process: 16/15881-0 - Epigenetics and gene expression analysis of the longevity vs. reproduction trade-off in Apis mellifera L. (Apidae, Hymenoptera) queens
Grantee:Carlos Antônio Mendes Cardoso Júnior
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/09269-3 - Methylome analysis of honey bee (Apis mellifera L.) worker ovaries in response to social condition
Grantee:Carlos Antônio Mendes Cardoso Júnior
Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)