| Full text | |
| Author(s): |
Llwyd, Osian
[1]
;
Salinet, Angela S. M.
[1, 2]
;
Panerai, Ronney B.
[1]
;
Lam, Man Y.
[1]
;
Saeed, Nazia P.
[1]
;
Brodie, Fiona
[1]
;
Bor-Seng-Shu, Edson
[2]
;
Robinson, Thompson G.
[1]
;
Nogueira, Ricardo C.
[2]
Total Authors: 9
|
| Affiliation: | [1] Univ Leicester, Dept Cardiovasc Sci Cerebral Haemodynam, Ageing & Stroke Med Res Grp, Leicester, Leics - England
[2] Univ Sao Paulo, Sch Med, Hosp Clin, Dept Neurol, Ave Doutor Arnaldo 455, BR-01246904 Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | CEREBROVASCULAR DISEASES EXTRA; v. 8, n. 2, p. 80-89, 2018. |
| Web of Science Citations: | 6 |
| Abstract | |
Background: Acute ischaemic stroke (AIS) patients often show impaired cerebral autoregulation (CA). We tested the hypothesis that CA impairment and other alterations in cerebral haemodynamics are associated with stroke subtype and severity. Methods: AIS patients (n = 143) were amalgamated from similar studies. Data from baseline (<48 h stroke onset) physiological recordings (beat-to-beat blood pressure {[}BP], cerebral blood flow velocity (CBFV) from bilateral insonation of the middle cerebral arteries) were calculated for mean values and autoregulation index (ARI). Differences were assessed between stroke subtype (Oxfordshire Community Stroke Project {[}OCSP] classification) and severity (National Institutes of Health Stroke Scale {[}NIHSS] score <5 and 5-25). Correlation coefficients assessed associations between NIHSS and physiological measurements. Results: Thirty-two percent of AIS patients had impaired CA (ARI <4) in affected hemisphere (AH) that was similar between stroke subtypes and severity. CBFV in AH was comparable between stroke subtype and severity. In unaffected hemisphere (UH), differences existed in mean CBFV between lacunar and total anterior circulation OCSP subtypes (42 vs. 56 cm.s(-1), p < 0.01), and mild and moderate-to-severe stroke severity (45 vs. 51 cm.s(-1), p = 0.04). NIHSS was associated with peripheral (diastolic and mean arterial BP) and cerebral haemodynamic parameters (CBFV and ARI) in the UH. Conclusions: AIS patients with different OCSP subtypes and severity have homogeneity in CA capability. Cerebral haemodynamic measurements in the UH were distinguishable between stroke subtype and severity, including the association between deteriorating ARI in UH with stroke severity. More studies are needed to determine their clinical significance and to understand the determinants of CA impairment in AIS patients. (c) 2018 The Author(s) Published by S. Karger AG, Basel (AU) | |
| FAPESP's process: | 13/25953-0 - Cerebral autoregulation in the acute and subacute phase of ischemic stroke patients submitted to thrombolysis |
| Grantee: | Ricardo de Carvalho Nogueira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/04955-8 - The natural history of the cerebral blood flow regulation after acute ischaemic stroke |
| Grantee: | Angela Salomao Macedo Salinet |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |