Geant4-DNA example applications for track structure simulations in liquid water: A report from the Geant4-DNA Project

Incerti, S.; Kyriakou, I.; Bernal, M. A.; Bordage, M. C.; Francis, Z.; Guatelli, S.; Ivanchenko, V.; Karamitros, M.; Lampe, N.; Lee, S. B.; Meylan, S.; Min, C. H.; Shin, W. G.; Nieminen, P.; Sakata, D.; Tang, N.; Villagrasa, C.; Tran, H. N.; Brown, J. M. C.

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Author(s): Show less -	Incerti, S. ^{[1, 2]} ; Kyriakou, I. ^[3] ; Bernal, M. A. ^[4] ; Bordage, M. C. ^{[5, 6]} ; Francis, Z. ^[7] ; Guatelli, S. ^{[8, 9]} ; Ivanchenko, V. ^{[10, 11]} ; Karamitros, M. ^[12] ; Lampe, N. ^[13] ; Lee, S. B. ^[14] ; Meylan, S. ^[15] ; Min, C. H. ^[16] ; Shin, W. G. ^{[1, 2, 16]} ; Nieminen, P. ^[17] ; Sakata, D. ^{[1, 2, 8]} ; Tang, N. ^[18] ; Villagrasa, C. ^[18] ; Tran, H. N. ^{[19, 20]} ; Brown, J. M. C. ^[21] Total Authors: 19
Affiliation: Show less -	^[1] Univ Bordeaux, CENBG, UMR 5797, F-33170 Gradignan - France ^[2] CNRS, UMR 5797, CENBG, IN2P3, F-33170 Gradignan - France ^[3] Univ Ioannina, Sch Med, Med Phys Lab, GR-45110 Ioannina - Greece ^[4] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas, SP - Brazil ^[5] Univ Toulouse III Paul Sabatier, UMR1037, CRCT, Toulouse - France ^[6] INSERM, UMR1037, CRCT, Toulouse - France ^[7] Univ St Joseph, Dept Phys, Fac Sci, Beirut - Lebanon ^[8] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW - Australia ^[9] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW - Australia ^[10] Tomsk State Univ, Tomsk - Russia ^[11] Geant4 Associates Int Ltd, Hebden Bridge - England ^[12] Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 - USA ^[13] Data Sci & Insights, Vicin Ctr, Off Tower One, 1341 Dandenong Rd, Chadstone, Vic 3148 - Australia ^[14] Natl Canc Ctr, Proton Therapy Ctr, 323 Ilsan Ro, Goyang Si, Gyeonggi Do - South Korea ^[15] SymAlgo Technol, 75 Rue Leon Frot, F-75011 Paris - France ^[16] Yonsei Univ, Dept Radiat Convergence Engn, Wonju - South Korea ^[17] ESA ESTEC, Noordwijk - Netherlands ^[18] IRSN, F-92262 Fontenay Aux Roses - France ^[19] Ton Duc Thang Univ, Fac Sci Appl, Ho Chi Minh City - Vietnam ^[20] Ton Duc Thang Univ, Adv Inst Mat Sci, Div Nucl Phys, Ho Chi Minh City - Vietnam ^[21] Delft Univ Technol, Dept Radiat Sci & Technol, Delft - Netherlands Total Affiliations: 21
Document type:	Journal article
Source:	Medical Physics; v. 45, n. 8, p. E722-E739, AUG 2018.
Web of Science Citations:	40
Abstract
This Special Report presents a description of Geant4-DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path...). These example applications are included in the Geant4 Monte Carlo toolkit and are available in open access. Each application is described and comparisons to recent international recommendations are shown (e.g., ICRU, MIRD), when available. The influence of physics models available in Geant4-DNA for the simulation of electron interactions in liquid water is discussed. Thanks to these applications, the authors show that the most recent sets of physics models available in Geant4-DNA (the so-called option4 and option 6 sets) enable more accurate simulation of stopping powers, dose point kernels, and W-values in liquid water, than the default set of models (option 2) initially provided in Geant4-DNA. They also serve as reference applications for Geant4-DNA users interested in TS simulations. (AU)

FAPESP's process:	11/51594-2 - Development of a computational system for the simulation of the interaction of ionizing radiations with the human genetic material
Grantee:	Mario Antonio Bernal Rodriguez
Support Opportunities:	Research Grants - Young Investigators Grants

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