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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Full text
Author(s):
Gabriel, Heloisa B. [1] ; Azevedo, Mauro F. [2] ; Kimura, Emilia A. [1] ; Katzin, Alejandro M. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biociencias, Santos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 113, n. 10 2018.
Web of Science Citations: 2
Abstract

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs. (AU)

FAPESP's process: 17/22452-1 - Biosynthesis of isoprenoids in Plasmodium falciparum: evaluation of possible targets to obtain new anti-malarial drugs
Grantee:Alejandro Miguel Katzin
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/23417-7 - Biosynthesis of isoprenoids in Plasmodium falciparum: evaluation of possible targets for to obtain new anti-malarial drugs
Grantee:Alejandro Miguel Katzin
Support Opportunities: Regular Research Grants
FAPESP's process: 15/12054-3 - Characterization of the biochemical and biological role of the MenA gene in asexual and sexual malarial stages
Grantee:Heloisa Berti Gabriel
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/19316-3 - Regulation of P. falciparum egress from the host cell: identification of new targets
Grantee:Mauro Ferreira de Azevedo
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 16/15298-3 - P. falciparum egress from the host cell: identification of new targets
Grantee:Mauro Ferreira de Azevedo
Support Opportunities: Scholarships in Brazil - Young Researchers