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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Selection scan reveals three new loci related to high altitude adaptation in Native Andeans

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Jacovas, Vanessa C. [1] ; Couto-Silva, Caina M. [2] ; Nunes, Kelly [2] ; Lemes, Renan B. [2] ; de Oliveira, Marcelo Z. [3] ; Salzano, Francisco M. [1] ; Bortolini, Maria Catira [1] ; Hunemeier, Tabita [2]
Total Authors: 8
[1] Univ Fed Rio Grande do Sul, Biosci Inst, Genet Dept, Porto Alegre, RS - Brazil
[2] Univ Sao Paulo, Biosci Inst, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil
[3] Vale do Rio dos Sinos Univ, Sao Leopoldo, RS - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, AUG 24 2018.
Web of Science Citations: 1

The Andean Altiplano has been occupied continuously since the late Pleistocene, similar to 12,000 years ago, which places the Andean natives as one of the most ancient populations living at high altitudes. In the present study, we analyzed genomic data from Native Americans living a long-time at Andean high altitude and at Amazonia and Mesoamerica lowland areas. We have identified three new candidate genes - SP100, DUOX2 and CLC - with evidence of positive selection for altitude adaptation in Andeans. These genes are involved in the TP53 pathway and are related to physiological routes important for high-altitude hypoxia response, such as those linked to increased angiogenesis, skeletal muscle adaptations, and immune functions at the fetus-maternal interface. Our results, combined with other studies, showed that Andeans have adapted to the Altiplano in different ways and using distinct molecular strategies as compared to those of other natives living at high altitudes. (AU)

FAPESP's process: 15/26875-9 - Native American genome diversity
Grantee:Tábita Hünemeier
Support type: Research Grants - Young Investigators Grants