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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reaching Biocompatibility with Nanoclays: Eliminating the Cytotoxicity of Ir(III) Complexes

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Author(s):
Gruner, Malte C. [1] ; Zanoni, Kassio P. S. [1] ; Borgognoni, Camila F. [2] ; Melo, Cristiane C. [2] ; Zucolotto, Valtencir [2] ; de Camargo, Andrea S. S. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Phys, Lab Spect Funct Mat LEMAF, Ave Trabalhador Saocarlense 400, BR-13566590 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Phys, Grp Nanomed & Nanotechnol GNano, Ave Trabalhador Saocarlense 400, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACS APPLIED MATERIALS & INTERFACES; v. 10, n. 32, p. 26830-26834, AUG 15 2018.
Web of Science Citations: 3
Abstract

Cyclometalated Ir-III complexes are promising candidates for biomedical applications but high cytotoxicity limits their use as imaging and sensing agents. We herein introduce the use of Laponite as carrier for triplet-emitting cyclometalated Ir-III complexes. Laponite is a versatile nanoplatform because of its biocompatibility, dispersion stability and large surface area that readily adsorbs functional nonpolar and cationic molecules. These inorganic - organic hybrid nanomaterials mask cytotoxicity, show efficient cell uptake and increase luminescent properties and photostability. By camouflaging intrinsic cytotoxicity, this simple method potentially extends the palette of available imaging and sensing dyes to any metal organic complexes, especially those that are usually cytotoxic. (AU)

FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 16/07706-4 - Nanocrystalline luminescent materials: new chemical concepts for energy conversion and sustainability
Grantee:Kassio Papi da Silva Zanoni
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/24118-6 - Study of light emitting nanoparticles (upconverting nanophores) for biomedical and biotechnological applications
Grantee:Malte Christian Gruener
Support Opportunities: Scholarships in Brazil - Post-Doctoral