| Full text | |
| Author(s): |
Balasco Serrao, Vitor Hugo
[1, 2]
;
Silva, Ivan Rosa
[1]
;
Alves da Silva, Marco Tulio
[1]
;
Scortecci, Jssica Fernandes
[1]
;
Fernandes, Adriano de Freitas
[1]
;
Thiemann, Otavio Henrique
[1, 3]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP - Brazil
[2] Harvard Med Sch, Dept Neurobiol, Boston, MA - USA
[3] Univ Fed Sao Carlos, Dept Genet & Evolut, Sao Carlos, SP - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | Amino Acids; v. 50, n. 9, p. 1145-1167, SEP 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Selenium (Se) is an essential trace element for several organisms and is mostly present in proteins as l-selenocysteine (Sec or U). Sec is synthesized on its l-seryl-tRNA(Sec) to produce Sec-tRNA(Sec) molecules by a dedicated selenocysteine synthesis machinery and incorporated into selenoproteins at specified in-frame UGA codons. UGA-Sec insertion is signaled by an mRNA stem-loop structure called the SElenoCysteine Insertion Sequence (SECIS). tRNA(Sec) transcription regulation and folding have been described showing its importance to Sec biosynthesis. Here, we discuss structural aspects of Sec-tRNA(Sec) and its role in Sec biosynthesis as well as Sec incorporation into selenoproteins. Defects in the Sec biosynthesis or incorporation pathway have been correlated with pathological conditions. (AU) | |
| FAPESP's process: | 11/24017-4 - Study of selenium metabolism in primitive eukaryotes |
| Grantee: | Marco Túlio Alves da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/20977-7 - Study of the selenocysteine incorporation pathway: understanding the macromolecular interaction mechanism |
| Grantee: | Jessica Fernandes Scortecci |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 13/17791-0 - Molecular and structural characterization of the Leishmania RNA virus LRV1-4 |
| Grantee: | Otavio Henrique Thiemann |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/23730-1 - Characterization of macromolecular interactions of proteins involved in the selenocysteine synthesis from Escherichia coli |
| Grantee: | Vitor Hugo Balasco Serrão |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 10/04429-3 - Structural Studies of Escherichia coli Selenophosphate Synthetase |
| Grantee: | Ivan Rosa e Silva |
| Support Opportunities: | Scholarships in Brazil - Master |