Effect of the trans-caryophyllene in the hypernociception induced by chronic const...
| Full text | |
| Author(s): |
Pizarro De Lorenzo, Beatriz Helena
[1]
;
Novaes E Brito, Ronni Romulo
[1]
;
Leal, Thatiane Paslar
[1]
;
Garcia, Nycole Piqueira
[1]
;
Martins dos Santos, Rafaela Miranda
[1]
;
Alvares-Saraiva, Anuska Marcelino
[1]
;
Perez Hurtado, Elizabeth Cristina
[2]
;
Braga dos Reis, Tania Carolina
[2]
;
Palma, Beatriz Duarte
[1]
Total Authors: 9
|
| Affiliation: | [1] Ctr Univ Sao Camilo, Ave Nazare 1-501, BR-04263200 Sao Paulo, SP - Brazil
[2] Univ Paulista, Inst Ciencias Saude, Pos Grad Patol Ambiental & Expt, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | NEUROIMMUNOMODULATION; v. 25, n. 2, p. 59-67, 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
Objectives: Sleep regulates immune function reciprocally and can affect the parameters that are directly involved in the immune response. Sleep deprivation is considered to be a stress-causing factor and is associated with impaired immune activity. It causes increased glucocorticoid concentrations by activating the hypothalamic-pituitary-adrenal axis; this can lead to a series of disorders that are associated with the prolonged or increased secretion of these hormones. The aim of this study was to evaluate the effects of sleep restriction (SR) on the development of pulmonary experimental metastasis and the modulation of the tumor immune response. Methods: The SR protocol was accomplished by depriving C57BL/6 male mice of sleep for 18 h/day for 2, 7, 14, and 21 days. The modified multiple-platforms method was used for SR. Results: The results showed that cytotoxic cells (i.e., natural killer {[}NK] and CD8+ T cells) were reduced in number and regulatory T cells were predominant in the tumor microenvironment. Sleep-restricted mice also exhibited a reduced number of dendritic cells in their lymph nodes, which may have contributed to the ineffective activation of tumor-specific T cells. Peripheral CD4+ and CD8+ T cells were also reduced in the sleep-restricted mice, thus indicating an immunosuppressive status. Conclusions: Sleep deprivation induces failure in the activity of cells that are important to the tumor immune response, both in the tumor microenvironment and on the periphery. This leads to the early onset and increased growth rate of lung metastasis. (C) 2018 S. Karger AG, Basel (AU) | |
| FAPESP's process: | 13/22963-5 - Effects of sleep deprivation on the development of metastasis in a murine melanoma model |
| Grantee: | Beatriz Duarte Palma Xylaras |
| Support type: | Regular Research Grants |