The impact of metabolic reprogramming on dendritic cell function

Author(s)

Thomaz, Livia de Lima ^[1] ; Peron, Gabriela ^[1] ; Oliveira, Janine ^[1] ; da Rosa, Larissa Camargo ^[1] ; Thome, Rodolfo ^[2] ; Verinaud, Liana ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil

^[2] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 - USA

• Document type: Review article
• Source: International Immunopharmacology; v. 63, p. 84-93, OCT 2018.
• Web of Science Citations: 2

Abstract

Dendritic cells (DCs) are antigen-presenting cells with the ability to activate naive T cells and direct the adaptive cellular immune response toward a specific profile. This is important, as different pathogens demand specific ``profiles{''} of immune responses for their elimination. Such a goal is achieved depending on the maturation/activation status of DCs by the time of antigen presentation to T cells. Notwithstanding this, recent studies have shown that DCs alter their metabolic program to accommodate the functional changes in gene expression and protein synthesis that follow antigen recognition. In this review, we aim to summarize the data in the literature regarding the metabolic pathways involved with DC phenotypes and their functions. (AU)

• FAPESP's process: 14/19492-3 - Influence of the mTOR, STAT1/3 and iNOS signaling pathways in the activity of tolerogenic dendritic cells
• Grantee: Liana Maria Cardoso Verinaud
• Support Opportunities: Regular Research Grants