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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Combining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Fever

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Vajana, Elia [1, 2, 3] ; Barbato, Mario [2, 3] ; Colli, Licia [2, 3] ; Milanesi, Marco [4, 2, 3, 5] ; Rochat, Estelle [1] ; Fabrizi, Enrico [6] ; Mukasa, Christopher [7, 8] ; Del Corvo, Marcello [2, 3] ; Masembe, Charles [9] ; Muwanika, Vincent B. [10] ; Kabi, Fredrick [11] ; Sonstegard, Tad Stewart [12] ; Huson, Heather Jay [13] ; Negrini, Riccardo [2, 3, 14] ; Joost, Stephane [1] ; Ajmone-Marsan, Paolo [2, 3] ; Consortium, NextGen
Total Authors: 17
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[1] Ecole Polytech Fed Lausanne, Sch Architecture Civil & Environm Engn ENAC, Lab Geog Informat Syst LASIG, Lausanne - Switzerland
[2] Univ Cattolica Sacro Cuore, Biodivers & Ancient DNA Res Ctr BioDNA, Dept Anim Sci Food & Nutr DIANA, Piacenza - Italy
[3] Univ Cattolica Sacro Cuore, Prote & Nutrigen Res Ctr PRONUTRIGEN, Piacenza - Italy
[4] Sao Paulo State Univ, Sch Vet Med, Dept Support Prod & Anim Hlth, Aracatuba - Brazil
[5] IAEA, Collaborating Ctr Anim Genom & Bioinformat, Aracatuba - Brazil
[6] Univ Cattolica Sacro Cuore, Dept Econ & Social Sci, Piacenza - Italy
[7] Natl Anim Genet Resource Ctr, Entebbe - Uganda
[8] Data Bank, Entebbe - Uganda
[9] Makerere Univ, Dept Zool Entomol & Fisheries, Kampala - Uganda
[10] Makerere Univ, Dept Environm Management, Kampala - Uganda
[11] Natl Agr Res Org, Natl Livestock Resources Res Inst NaLIRRI, Tororo - Uganda
[12] Recombinetics Inc, St Paul, MN - USA
[13] Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 - USA
[14] AIA, Rome - Italy
Total Affiliations: 14
Document type: Journal article
Source: FRONTIERS IN GENETICS; v. 9, OCT 3 2018.
Web of Science Citations: 2

East Coast fever (ECF) is a fatal sickness affecting cattle populations of eastern, central, and southern Africa. The disease is transmitted by the tick Rhipicephalus appendiculatus, and caused by the protozoan Theileria parva parva, which invades host lymphocytes and promotes their clonal expansion. Importantly, indigenous cattle show tolerance to infection in ECF-endemically stable areas. Here, the putative genetic bases underlying ECF-tolerance were investigated using molecular data and epidemiological information from 823 indigenous cattle from Uganda. Vector distribution and host infection risk were estimated over the study area and subsequently tested as triggers of local adaptation by means of landscape genomics analysis. We identified 41 and seven candidate adaptive loci for tick resistance and infection tolerance, respectively. Among the genes associated with the candidate adaptive loci are PRKG1 and SLA2. PRKG1 was already described as associated with tick resistance in indigenous South African cattle, due to its role into inflammatory response. SLA2 is part of the regulatory pathways involved into lymphocytes' proliferation. Additionally, local ancestry analysis suggested the zebuine origin of the genomic region candidate for tick resistance. (AU)

FAPESP's process: 16/05787-7 - Combining high-density SNP genotypes and next generation sequence data to map disadvantageous genetic variants in Nellore cattle
Grantee:Marco Milanesi
Support type: Scholarships in Brazil - Post-Doctorate