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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of insulin at brain-liver axis in the control of glucose production

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Author(s):
Ramos Ribeiro, Izabela Martina [1] ; Antunes, Vagner Roberto [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Prof Lineu Prestes 1524, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY; v. 315, n. 4, p. G538-G543, OCT 2018.
Web of Science Citations: 0
Abstract

Glucose is an essential metabolic substrate for all mammalian cells, and its availability in the circulation is carefully controlled to avoid wide variations. Different mechanisms are involved in the glucose disposal, such as an adequate pancreatic and hepatic function. Insulin is the main hormone in glycemic control, and its action occurs directly in the cells, as well as in the liver, in an indirect way, to ultimately control the glycemia. Insulin has also an important action within the central nervous system, more precisely in the hypothalamus that projects directly to preautonomic nuclei in the brain stem to control hepatic glucose production. The central action of insulin relies on autonomic outflow through the vagal innervation of the liver, where insulin is able to modulate the production of glucose at this organ level. In this way, responses generated in the CNS reach the effector organs by autonomic efferent pathways as part of an important brain-organ axis in the control of glycemia. The purpose of this minireview is to shed light on the brain-liver axis in the control of hepatic glucose by central action of insulin via the autonomic nervous system. (AU)

FAPESP's process: 13/06206-0 - Gene expression changes of neuropeptides and proinflammatory factors of the hypothalamus and brainstem nucleus involved with cardiovascular regulation in diet-induced obesity animals
Grantee:Vagner Roberto Antunes
Support type: Regular Research Grants
FAPESP's process: 09/13047-0 - Role of the autonomic nervous system in the hepatic production of glucose via central action of insulin in hypertensive animals
Grantee:Izabela Martina Ramos Ribeiro de Toledo
Support type: Scholarships in Brazil - Master