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Role of the autonomic nervous system in the hepatic production of glucose via central action of insulin in hypertensive animals

Grant number: 09/13047-0
Support type:Scholarships in Brazil - Master
Effective date (Start): April 01, 2010
Effective date (End): March 31, 2012
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Vagner Roberto Antunes
Grantee:Izabela Martina Ramos Ribeiro de Toledo
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The capacity of the human body to preserve energy reserves in situations of food abundance with the aim of generating surplus stores critical for vital organ function, during periods of famine, is of extreme importance. Insulin is one of the major hormones responsible for this function. In post-absorption, insulin promotes the uptake of glucose by peripheral tissues, especially by those expressing GLUT4. Generally, hepatic glucose production (HGP) is determined by the rate of glycogenesis and glycogenolysis. Insulin exerts a potent hepatic action resulting in suppression of HGP. Sympathetic activation increases HGP by stimulating both glycogenolysis and glycogenesis. Stimulation of glycogenesis is driven by the increase of circulating catecholamines secreted by the adrenal medulla and post-ganglionic release of catecholamines by sympathetic fibers that innervate the liver while parasympathetic activation results in decreased HGP. Despite metabolic modulation of the direct glycogenesis by insulin being relatively well defined, little is known about the indirect regulation of HGP mediated by insulin's actions in territories outside the liver and the transmission of information from the central nervous system to the liver. Moreover, it is not yet well known how the sympathetic and vagal autonomic balance operates as a consequence of the central actions of insulin. Thus, the purpose of this study is to investigate the effects of insulin injected into the central nervous system, on HGP, the expression of PEPCK and G-6-pase in this organ and evaluate if these changes are dependent on sympathetic hyperactivity in hypertensive animals.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAMOS RIBEIRO, IZABELA MARTINA; ANTUNES, VAGNER ROBERTO. The role of insulin at brain-liver axis in the control of glucose production. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, v. 315, n. 4, p. G538-G543, OCT 2018. Web of Science Citations: 0.
RIBEIRO, NATALIA; PANIZZA, HELENA DO NASCIMENTO; DOS SANTOS, KAROLINE MARTINS; FERREIRA-NETO, HILDEBRANDO C.; ANTUNES, VAGNER ROBERTO. Salt-induced sympathoexcitation involves vasopressin V-1a receptor activation in the paraventricular nucleus of the hypothalamus. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 309, n. 11, p. R1369-R1379, DEC 1 2015. Web of Science Citations: 10.
RIBEIRO, IZABELA MARTINA R.; FERREIRA-NETO, HILDEBRANDO C.; ANTUNES, VAGNER R. Subdiaphragmatic vagus nerve activity and hepatic venous glucose are differentially regulated by the central actions of insulin in Wistar and SHR. PHYSIOLOGICAL REPORTS, v. 3, n. 5 MAY 2015. Web of Science Citations: 4.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TOLEDO, Izabela Martina Ramos Ribeiro de. Central action of insulin and the sympathetic nervous system on hepatic glucose production of conscious rats.. 2012. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas São Paulo.

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