New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects

Author(s)

Davel, Ana Paula ^[1] ; Jaffe, Iris Z. ^[2] ; Tostes, Rita C. ^[3] ; Jaisser, Frederic ^[4] ; de Chantemele, Eric J. Belin ^[5]

Affiliation

^[1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil

^[2] Tufts Med Ctr, Mol Cardiol Res Inst, Boston, MA - USA

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP - Brazil

^[4] Paris Descartes Univ, Pierre & Marie Curie Univ, Ctr Rech Cordeliers, UMRS 1138, INSERM, Paris - France

^[5] Augusta Univ, Med Coll Georgia, Vasc Biol Ctr, 1459 Laney Walker Blvd, Augusta, GA 30912 - USA

• Document type: Review article
• Source: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 315, n. 4, p. H989-H999, OCT 2018.
• Web of Science Citations: 5

Abstract

Recent advances in the field of mineralocorticoid receptor (MR) and its ligand aldosterone expanded the role of this hormone and its receptor far beyond their initial function as a regulator of Na+ and K+ homeostasis in epithelial cells. The symposium ``New Roles of Aldosterone and Mineralocorticoid Receptors in Cardiovascular Disease: Translational and Sex-Specific Effects{''} presented at the 38th World Congress of the International Union of Physiological Sciences (Rio de Janeiro, Brazil) highlighted the contribution of extrarenal MRs to cardiovascular disease. This symposium showcased how MRs expressed in endothelial, vascular smooth muscle, and immune cells plays a critical role in the development of vascular disease associated with aging, obesity, and chronic aldosterone stimulation and demonstrated that MR antagonism prevents the acute renal dysfunction and tubular injury induced by ischemia-reperfusion injury. It was also shown that the adipocyte-derived hormone leptin is a new direct regulator of aldosterone secretion and that leptin-mediated aldosterone production is a major contributor to obesity-associated hypertension in women. Sex differences in the role of aldosterone and of endothelial MR in the cardiovascular outcomes of obesity were highlighted. This review summarizes these important emerging concepts regarding the contribution of aldosterone and cell-specific MR to cardiovascular disease in male and female subjects and further supports sex-specific benefits of MR antagonist drugs to be tested in additional populations. (AU)

• FAPESP's process: 14/26192-6 - Role of endothelial mineralocorticoid receptor on the endothelial dysfunction and oxidative stress in cardiovascular diseases
• Grantee: Ana Paula Couto Davel
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 17/10771-5 - IUPS 38th WORLD CONGRESS
• Grantee: Ana Paula Couto Davel
• Support Opportunities: Research Grants - Meeting - Brazil