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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lipid profile associated with the systemic inflammatory response syndrome and sepsis in critically ill patients

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Brigatto Simoes Golucci, Ana Paula [1] ; Lima Marson, Fernando Augusto [2, 1, 3] ; Ribeiro, Antonio Fernando [1] ; Negrao Nogueira, Roberto Jose [1, 3, 4]
Total Authors: 4
[1] Univ Estadual Campinas, Fac Med Sci, Dept Pediat, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Dept Med Genet, Sao Paulo - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, Ctr Res Pediat, Sao Paulo - Brazil
[4] Sao Leopoldo Mandic Fac, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Review article
Source: NUTRITION; v. 55-56, p. 7-14, NOV-DEC 2018.
Web of Science Citations: 2

Objectives: Changes in lipid profiles occur in systemic inflammatory response syndrome (SIRS), whether due to sepsis or another cause. Hypocholesterolemia associated with hypertriacylglycerolemia can lead to disease severity and higher mortality. The aim of this systematic review was to describe the principal alterations in markers that participate in the alteration of the lipid profile. Methods: We reviewed articles focused on alterations in the lipid profile in SIRS, sepsis, or both that were indexed in the Scientific Electronic Library Online from 2000 to 2017. The descriptors used were SIRS; sepsis; lipid profile; and lipoproteins. We focused in particular on the relationships among SIRS, sepsis, and lipid profiles. Results: We included 29 studies that discussed decreased high-density lipoprotein (HDL), total cholesterol. and low-density lipoprotein, and elevated triacylglycerols concentrations in patients with SIRS, sepsis, or both. The variation in the lipid profile was proportional to the level of inflammation as evaluated by inflammatory markers, including C-reactive protein, interleukin-6 and interleukin-8, lipopolysaccharide-binding protein, and tumor necrosis factor. Additionally, there was a change in the composition of lipoproteins, especially HDL, triacylglycerols, and very low-density lipoprotein. HDL appears to be an inflammatory marker, as reduction of its levels reflects the intensity of the underlying inflammatory process. Conclusion: Critically ill patients with SIRS, sepsis, or both presented with alterations in lipid metabolism. (C) 2018 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 15/12858-5 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
Grantee:Fernando Augusto de Lima Marson
Support type: Scholarships in Brazil - Post-Doctorate