NbCl5 a multifunctional reagent for the synthesis of new halogenated aminoquinoline compounds through innovative one-pot reaction and the acidochromism effect

Author(s)

dos Santos, Giovanny Carvalho ^[1] ; Moreno, Vitor Fernandes ^[1] ; Oshiro, Paula Beatriz ^[1] ; da Silva-Filho, Luiz Carlos ^[1]

Affiliation

^[1] Sao Paulo State Univ, UNESP, Dept Chem, LOSP, Sch Sci, BR-17033360 Bauru, SP - Brazil

• Document type: Journal article
• Source: Tetrahedron; v. 74, n. 42, p. 6144-6149, OCT 18 2018.
• Web of Science Citations: 2

Abstract

This paper describes an original one-pot way to synthesize nine new halogenated aminoquinoline derivatives using reactions conducted by niobium pentachloride. Subsequently, we describe an efficient and selective reduction reaction of nitroquinolines using niobium pentachloride and zinc, producing important compounds in the organic synthesis. The results showed that it is an important tool to synthesize these compounds, besides being time and resources-saving and generating good yields. A quick study of acidochromism was performed. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 12/24199-8 - Studies on synthesis of Quinoline derivatives promoted by Niobium Pentachloride, for use as dyes-sensitizers in photoelectrochemical devices of Grätzel
• Grantee: Giovanny Carvalho dos Santos
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/00615-0 - Studies on the synthesis and photochemical and photophysical characterization of quinoline derivatives with donor-p-acceptor structure for use as sensitizing dyes in organic electronic devices
• Grantee: Giovanny Carvalho dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/14506-7 - Study about the one-pot synthesis and application as organic dyes of quinolone and anthrazoline derivatives
• Grantee: Luiz Carlos da Silva Filho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/01599-1 - Studies about the use of NbCl5 in multicomponent reactions for the synthesis of organic dyes
• Grantee: Luiz Carlos da Silva Filho
• Support Opportunities: Regular Research Grants