| Full text | |
| Author(s): |
Mariz, Bruno A. L. A.
[1]
;
Soares, Ciro D.
[1]
;
Morais, Thayna M. L.
[1]
;
Fonseca, Felipe P.
[2]
;
de Carvalho, Maria G. F.
[3]
;
Jorge, Jacks
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil
[2] Univ Fed Minas Gerais, Belo Horizonte, MG - Brazil
[3] Univ Potiguar, Dept Oral Pathol, Natal, RN - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 47, n. 9, p. 816-822, OCT 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Fibroblast growth factor 2 (FGF-2) is a multifunctional cytokine expressed in several tissues and involved in a wide variety of biologic activities, with one low molecular weight (LMW) protein present in the cytosol, which is secreted, acting via its receptors (FGFRs), and four high molecular weight (HMW) proteins located in the nucleus. Fibroblast growth factor receptor (FGFR) family has four (FGFR1-4) transmembrane tyrosine kinase receptors expressed on several cell types, and FGFR-1 has been indicated as a potential molecular target in several types of cancer, including oral squamous cell carcinoma (OSCC). The FGF-2/FGFR-1 expression has been studied in the oral cavity, and it was associated with the wound repair process, the development of benign and malignant salivary gland tumors, besides being related to oral potentially malignant disorders (OPMDs) and OSCC. Hence, we critically review the currently available data on FGF-2/FGFR-1 expression in the normal mucosa and lesions of the oral cavity. (AU) | |
| FAPESP's process: | 17/16102-8 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas |
| Grantee: | Jacks Jorge Junior |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity |
| Grantee: | Ciro Dantas Soares |
| Support Opportunities: | Scholarships in Brazil - Doctorate |