Giant dentinogenic ghost cell tumor: A case report

Author(s)

Soares, Ciro Dantas ^[1] ; Carlos, Roman ^[2] ; de Lima Morais, Thayna Melo ^[1] ; de Almeida, Oslei Paes ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Dept Oral Diag, Piracicaba Dent Sch, Piracicaba, SP - Brazil

^[2] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Div, Guatemala City - Guatemala

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 126, n. 4, p. E215-E219, OCT 2018.
• Web of Science Citations: 0

Abstract

Dentinogenic ghost cell tumor (DGCT), a rare, benign odontogenic tumor with aggressive behavior, causes bone destruction and cortical expansion. We report here a case of DGCT in a 38-year-old male, presenting with enormous extraoral protrusion, which radiographically was predominantly radiolucent with radiopaque areas. Microscopically, it was observed to be a solid ameloblastomatous proliferation with pseudoglandular structures associated with clusters of ghost cells. Abundant dentinoid material adjacent to the epithelial sheets containing entrapped epithelial tumor cells was also evident. lrnmunohistochernistry revealed positivity for pan-cytokeratin (CK), CK-14, CK-7, and CK-19; CD138; and beta-catenin. The Ki-67 proliferative index was very low (<1%). The clinical, histopathologic, and immunohistochemical features led to the diagnosis of DGCT. The patient underwent partial mandibulectomy, and no recurrences have occurred. To our knowledge, this is the largest DGCT described in the English language literature. (AU)

• FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
• Grantee: Ciro Dantas Soares
• Support Opportunities: Scholarships in Brazil - Doctorate