Liphaus, Bernadete L.
Sallum, Adriana E. M.
Aikawa, Nadia E.
Kiss, Maria Helena B.
Silva, Clovis A.
Total Authors: 10
 Univ Sao Paulo, Fac Med, Childrens Inst, Lab Med Invest, Sao Paulo - Brazil
 Univ Sao Paulo, Fac Med, Childrens Inst, Pediat Rheumatol Unit, Sao Paulo - Brazil
 Univ Sao Paulo, Fac Med, Sao Paulo - Brazil
 Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Sao Paulo - Brazil
Total Affiliations: 4
JOURNAL OF RHEUMATOLOGY;
NOV 1 2018.
Web of Science Citations:
Objective. To evaluate soluble Fas antigen (sFas), sFas ligand (sFasL), soluble tumor necrosis factor-related apoptosis-inducing ligand, and soluble cytoplasmic Bcl-2 protein (sBcl-2) serum levels, Fas and Bcl-2 expressions in T and B lymphocytes and monocytes and relations with erythrocyte sedimentation rate, C-reactive protein (CRP), Childhood Myositis Assessment Scale, and manual muscle testing in juvenile dermatomyositis (JDM). Methods. Serum levels were determined by ELISA and peripheral cell expressions by flow cytometry for patients with JDM or juvenile idiopathic arthritis (JIA), and healthy controls. Results. Patients with JDM had increased sBcl-2, which correlated with CRP. Expression of Bcl-2 was increased and expression of Fas was decreased in CD3+, CD4+, and CD8+ T lymphocytes compared with JIA and/or healthy controls. Conclusion. Patients with JDM presented a unique apoptosis-related proteins profile, which may contribute to disease development. (AU)