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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interleukin-10 and collagen type II immunoexpression are modulated by photobiomodulation associated to aerobic and aquatic exercises in an experimental model of osteoarthritis

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Author(s):
Assis, Livia [1, 2] ; Tim, Carla [1, 2] ; Magri, Angela [1] ; Fernandes, Kelly Rossetti [1] ; Vassao, Patricia Gabrielli [1] ; Muniz Renno, Ana Claudia [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Santos, SP - Brazil
[2] Univ Brasil, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Lasers in Medical Science; v. 33, n. 9, p. 1875-1882, DEC 2018.
Web of Science Citations: 5
Abstract

The aim of this study was to compare the effects of photobiomodulation (PBM) associated with an aerobic and an aquatic exercise training on the degenerative process related to osteoarthritis (OA) in the articular cartilage in rats. Fifty male Wistar rats were randomly divided into 5 groups: OA control group (CG), OA plus aerobic training group (AET), OA plus aquatic training group (AQT), OA plus aerobic training associated with PBM group (AETL), OA plus aquatic training associated with PBM group (AQTL). The aerobic training (treadmill; 16m/min; 50min/day) and the aquatic training (water jumping; 50-80% of their body mass) started 4weeks after the surgery and they were performed 3days/week for 8weeks. Moreover, PBM was performed after the physical exercise trainings on the left joint. Morphological characteristics and immunoexpression of IL-10, TGF-, and collagen type I (Col I) and II (Col II) of the articular cartilage were evaluated. The results showed that all the treated groups (exercise and PBM) presented less intense signs of degradation (measured by histopathological analysis and OARSI grade system). Additionally, aerobic and aquatic exercise training rats (associated or not with PBM) showed increased IL-10 (AET p=0.0452; AETL p=0.03; AQTL p=0.0193) and Col II (AET p=0.012; AQT p=0.0437; AETL p=0.0001; AQTL p=0.0001) protein expression compared to CG. Furthermore, a statistically higher TGF- expression was observed in AET (p=0.0084) and AETL (p=0.0076) compared to CG. These results suggest that PBM associated with aerobic and aquatic exercise training were effective in mediating chondroprotective effects and maintaining the integrity of the articular tissue in the knees of OA rats. (AU)

FAPESP's process: 12/20145-0 - Effects of physical exercise and low-level laser therapy on knee osteoarthritis induced by transection of the anterior cruciate ligament in rats
Grantee:Lívia Assis Garcia
Support type: Scholarships in Brazil - Post-Doctorate